Results 51 to 60 of about 357,503 (297)

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

A MULTIVARIATE WALD-WOLFOWITZ RANK TEST AGAINST SERIAL DEPENDENCE [PDF]

The Canadian Journal of Statistics / La Revue Canadienne de Statistique, 1995
Summary: Rank-based cross-covariance matrices, extending to the case of multivariate observed series the (univariate) rank autocorrelation coefficients introduced by \textit{A. Wald} and \textit{J. Wolfowitz} [Ann. Math. Stat. 14, 378-388 (1943; Zbl 0060.302)], are considered.
Hallin, Marc, Puri, Madan L.
openaire   +1 more source

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

On the Formulation of Wald Tests of Nonlinear Restrictions [PDF]

Econometrica, 1988
Summary: This paper utilizes asymptotic expansions of the Edgeworth type to investigate alternative forms of the Wald test of nonlinear restrictions. Some formulae for the asymptotic expansion of the distribution of the Wald statistic are provided for a general case that should include most econometric applications. When specialized to the simple cases
Phillips, Peter C B, Park, Joon Y
openaire   +2 more sources

Asymptotic formulae for likelihood-based tests of new physics [PDF]

, 2011
We describe likelihood-based statistical tests for use in high energy physics for the discovery of new phenomena and for construction of confidence intervals on model parameters. We focus on the properties of the test procedures that allow one to account
Cowan, Glen, Cranmer, Kyle, Gross, Eilam, Vitells, Ofer   +3 more
core   +3 more sources

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Computational Approach Test using Likelihood Based Tests for the Equality of Inverse Gaussian Means

Revstat Statistical Journal
In this study, we propose three different test procedures by plugging the Wald (W), score (S) and likelihood ratio (LR) statistics into the computational approach test (CAT) to test the equality of inverse Gaussian means when the scale parameters are ...
Gamze Güven , Hatice Şamkar, Fikri Gökpinar   +2 more
doaj   +1 more source

Inference in the indeterminate parameters problem

Statistica, 2013
We face an indeterminate parameters problem when there are two sets of parameters, x and g, say, such that the null hypothesis H0:x=x0 makes the likelihood independent of g. A consequence of indeterminacy is the singularity of the information matrix. For
Marco Barnabani
doaj   +1 more source

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

Fast score test with global null estimation regardless of missing genotypes. [PDF]

PLoS ONE, 2018
In genome-wide association studies (GWASs) for binary traits (or case-control samples) in the presence of covariates to be adjusted for, researchers often use a logistic regression model to test variants for disease association.
Shuntaro Sato, Masao Ueki, Alzheimer’s Disease Neuroimaging Initiative   +2 more
doaj   +1 more source