Results 51 to 60 of about 2,806 (137)

Impact of FCGR2A and FCGR3A Gene Variants on the Response to Rituximab in Patients With Glomerular Diseases

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Rituximab is an anti‐CD20 monoclonal antibody used in autoimmune diseases, including glomerular diseases. The FCGR2A (rs1801274) and FCGR3A (rs396991) variants have been suggested to affect rituximab efficacy; this study evaluates their impact on rituximab efficacy in glomerular diseases.
María Larrosa‐García, Irene Agraz Pamplona, Susana Rojo Tolosa, Alberto Jiménez Morales, María Teresa Sanz Martínez, Mónica Martínez Gallo, Roger Colobran, Helena Genestal Vicente, Nerea Moreno Pena, Roxana Paola Bury Macías, José Bruno Montoro Ronsano   +10 more
wiley   +1 more source

Monoclonal gammopathy of undetermined significance : natural course and comorbidities [PDF]

, 2017
Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell disorder characterized by an overproduction of monoclonal immunoglobulins.
Lindqvist, Ebba K
core   +1 more source

Neoplasm Adverse Events Associated With Anti‐Type 2 Biologics: An FAERS Database Pharmacovigilance Analysis Study

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Biologics targeting Type 2 immune responses, such as omalizumab (anti‐IgE), dupilumab (anti‐interleukin‐4 receptor alpha, anti‐IL‐4Rα), benralizumab (anti‐IL‐5R), reslizumab, and mepolizumab (anti‐IL‐5), are increasingly used clinically.
Wen Lyu, Rui Xu, Lin Chen, Wenbin Lei, Changhui Chen, Jiaqi Liao, Xingyu Lin, Renqiang Ma, Weiping Wen, Hang Li   +9 more
wiley   +1 more source

Incidence of Pneumocystis jiroveci Pneumonia among Groups at Risk in HIV-negative Patients

, 2014
International audienceBackground - Pneumocystis jiroveci pneumonia in human immunodeficiency virus (HIV)-negative immunocompromised patients is associated with high mortality rates.
Decaux, Olivier, Fillâtre, Pierre, Fresnel, Annie, Gacouin, Arnaud, Guiguen, Claude, Jouneau, Stéphane, Jégo, Patrick, Le Tulzo, Yves, Revest, Matthieu, Robert-Gangneux, Florence, Tattevin, Pierre   +10 more
core   +3 more sources

RESCUE OF HIPPO CO-ACTIVATOR YAP1 TRIGGERS DNA DAMAGE-INDUCED APOPTOSIS IN HEMATOLOGICAL CANCERS [PDF]

, 2014
Oncogene–induced DNA damage elicits genomic instability in epithelial cancer cells, but apoptosis is blocked through inactivation of the tumor suppressor p53. In hematological cancers, the relevance of ongoing DNA damage and mechanisms by which apoptosis
Alec C Kimmelman, Antonino Neri, BA Walker, BL Bennett, Chunxiao Xu, CL Creasy, CM Annunziata, D Levy, D Levy, D Pan, D Zhou, D Zhou, DK Walters, DR Carrasco, E Bertini, E Lapi, E White, Elena Antonini, Elisa ten Hacken, Federico Caligaris-Cappio, Francesca Cottini, Giovanni Blandino, Giovanni Tonon, I Hickson, J Bartkova, JJ Keats, K Tschop, K Yoshida, Kenneth C Anderson, KF Harvey, Kwok-Kin Wong, L Brown, Luca Agnelli, M Sudol, MA Chapman, Magda Marcatti, Maria Teresa Bertilaccio, Martin Sattler, Martina Dori, Maurilio Ponzoni, N Reuven, Paul G Richardson, R Baskaran, Ruben Carrasco, S Basu, S Boehrer, S Kharbanda, S Piccolo, S Strano, S Strano, T Shafman, TD Halazonetis, Teru Hideshima, VG Gorgoulis, W Michael Kuehl, WG Kaelin Jr., ZM Yuan, ZM Yuan, ZY Xu-Monette   +58 more
core   +2 more sources

Renal MALT lymphoma associated with Waldenström macroglobulinemia

Journal of the Formosan Medical Association, 2014
Mucosa associated lymphoid tissue lymphoma (MALT lymphoma) is mostly seen in the gastrointestinal tract; origin from the kidney is extremely rare. Waldenström macroglobulinemia (WM) is a clinicopathologic syndrome denoted by the presence of monoclonal ...
Po-Jui Chi, Sung-Nan Pei, Tung-Liang Huang, Shun-Chen Huang, Hwee Yeong Ng, Chien-Te Lee   +5 more
doaj   +1 more source

Comparative Analysis of Four Matrix Dilution Methods for Eliminating IgM Paraprotein Interference in Prealbumin and Uric Acid Assays: Based on Two Case Reports

Journal of Clinical Laboratory Analysis, Volume 40, Issue 9, May 2026.
IgM paraproteins can cause significant interference in prealbumin (PA) and uric acid (UA) measurements, leading to falsely abnormal results. We systematically compared four dilution methods to eliminate this interference. Dilution with the PA reagent (containing PEG) effectively restored accurate PA results.
Xiaowei Chi, Zihan Liu, Weifang Liu, Huihui Jiang, Denglu Zhang   +4 more
wiley   +1 more source

Cast nephropathy: an extremely rare renal presentation of Waldenström's macroglobulinaemia [PDF]

, 2015
Renal involvement in Waldenström's macroglobulinaemia (WM) is very unusual when compared to multiple myeloma. We report a case of a patient who developed anuric acute kidney injury secondary to cast nephropathy, dependent on high-flux haemodialysis ...
Campos, M, Machado, S, Santos, T, Sousa, V   +3 more
core   +1 more source

Population Pharmacokinetic Modeling and Exposure‐Response Analyses of Nemtabrutinib in Patients With Hematologic Malignancies

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Nemtabrutinib is a Bruton's tyrosine kinase (BTK) inhibitor under clinical investigation in patients with hematologic malignancies, including chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL). Nemtabrutinib plasma concentration data from 578 patients enrolled in phase 1 and 2 clinical studies, treated with doses from 5 to ...
Chiara C. Kemal, Thijs J. Zweers, Elke H. J. Krekels, Manash S. Chatterjee   +3 more
wiley   +1 more source

Autoantibodies in systemic vasculitis [PDF]

, 2015
Systemic vas culitis is a heterogeneous group of disorders characterized by inflammation and necrosis in the vessel wall. the diagnosis of a systemic vasculitis is challenging, because patients usually present a broad spectrum of manifestations that vary
Souza, Alexandre Wagner Silva de
core   +3 more sources