Results 91 to 100 of about 18,042 (202)

A CACNA2D2‐Related Recessive Form of Cerebellar Abiotrophy in Angus Cattle

Animal Genetics, Volume 57, Issue 2, April 2026.
ABSTRACT Cerebellar disease in ruminants is often virus‐induced and non‐genetic, but there are also rare inherited forms of cerebellar hypoplasia and cerebellar abiotrophy (CA). So far, no causal variant has been reported for these conditions in cattle. Two inbred Angus calves suspected of having cerebellar disease were reported in Scotland.
Joana Jacinto, Francesca Chianini, Jo Moore, Timothy Geraghty, Irene M. Häfliger, Franz R. Seefried, Alwyn Jones, Helen Carty, Anna Letko, Cord Drögemüller   +9 more
wiley   +1 more source

Axonal and neuromuscular synaptic phenotypes in Wld(S), SOD1(G93A) and ostes mutant mice identified by fiber-optic confocal microendoscopy [PDF]

, 2009
We used live imaging by fiber-optic confocal microendoscopy (CME) of yellow fluorescent protein (YFP) expression in motor neurons to observe and monitor axonal and neuromuscular synaptic phenotypes in mutant mice.
Blanco, Gonzalo, Brown, Rosalind, Coleman, Michael P., Fan, Li, Hartley, Robert, Mackenzie, Francesca E., Oyebode, Oyinlola, Ribchester, Richard R., Thomson, Derek, Wells, Sara, Wong, Frances   +10 more
core   +1 more source

Neurofilament Proteoforms in Amyotrophic Lateral Sclerosis Are Different in Cerebrospinal Fluid and Blood

Annals of Neurology, Volume 99, Issue 4, Page 857-862, April 2026.
We used targeted immunopurification‐mass spectrometry (IP‐MS) to characterize human neurofilament light chain (NfL) proteoforms across various compartments to assess their alterations in amyotrophic lateral sclerosis (ALS). NfL is truncated in cerebrospinal fluid (CSF) and blood in patients with sporadic ALS (sALS) and these proteoforms differ between ...
John B. Coulton, Yingxin He, Melissa M. Budelier, Nicolas Barthélemy, Margaret D. Ireland, Miwei Hu, Danielle Graham, Toby Ferguson, James D. Berry, Randall J. Bateman, Timothy M. Miller, Cindy V. Ly   +11 more
wiley   +1 more source

Retrograde trans-synaptic degeneration of visual pathway in an adult with head injury

Kerala Journal of Ophthalmology, 2016
A 41-year-old male with a history of head injury 16 years previously but no visual deficit, presented with reading difficulty. Examination showed disc pallor bilaterally, and perimetry showed the left homonymous hemianopsia.
Thomas Arun Varghese, Annamma James, Cigia Paul   +2 more
doaj   +1 more source

The Role of Neuritin 1 in Synaptic Plasticity and Sensory Nerve Function: Integrator of Neurotrophic, Metabolic and Injury Signals

European Journal of Neuroscience, Volume 63, Issue 7, April 2026.
Neuritin 1 (NRN1) is a multifaceted regulator of synaptic plasticity, neuronal excitability and structural remodelling, acting as a molecular integrator of neurotrophic, metabolic and injury‐associated signals that coordinate adaptive plasticity.
Jyoti Agrawal, Mar Vives Escola, Simon W. Jones, Victoria Chapman, Federico Dajas‐Bailador   +4 more
wiley   +1 more source

Proper microsurgical nerve suture may impede Wallerian degeneration of completely transected nerves: an electron microscopic study

Arquivos de Neuro-Psiquiatria, 1983
Electron microscopic findings on the nerve of the biventer cervicis muscle of the chick, which was completely transected and immediately after submitted to an adequate microsurgical nerve suture, confirmed our previous statement that proper microsurgical
Eros Abrantes Erhart, Ciro Ferreira da Silva, Claudio Fava Chagas   +2 more
doaj   +1 more source

Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes [PDF]

, 2011
Background Traumatic injury to axons produces breakdown of axons and myelin at the site of the lesion and then further distal to this where Wallerian degeneration develops.
Miri Gitik, Sigal Liraz-Zaltsman, Per-Arne Oldenborg, Fanny Reichert, Shlomo Rotshenker   +4 more
core   +2 more sources

Extracorporeal Shock Wave Therapy Promotes Peripheral Nerve Regeneration Through ERK1/2‐Mediated Autophagy

Annals of the New York Academy of Sciences, Volume 1558, Issue 1, April 2026.
Extracorporeal shock wave therapy (SWT) promotes structural and functional recovery following sciatic nerve injury. This study demonstrates that SWT activates the ERK1/2 signaling pathway in Schwann cells, which in turn upregulates autophagic flux.
Xingdong Xiang, Xiaoqiong Wu, Shen Ling, Junwen Zhu, Jian Zhang, Tengfei Fu   +5 more
wiley   +1 more source

Activity of Cyclic AMP Phosphodiesterases and Adenylyl Cyclase in Peripheral Nerve after Crush and Permanent Transection Injuries [PDF]

, 1998
Recent studies demonstrate that cAMP levels are tightly controlled during demyelination and remyelination in Schwann cells as cAMP decreases to 8–10% of normal following both sciatic nerve crush or permanent transection injury and only begins to increase
Poduslo, Joseph F., Walikonis, Randall S.   +1 more
core   +1 more source

Wallerian degeneration of the corticospinal tracts [PDF]

Neurology, 2004
A 35-year-old woman experienced acute onset of neck pain with dysarthria and left-sided weakness. Neurologic examination revealed a right-sided Horner’s syndrome, left facial palsy, and left hemiparesis. The diagnostic evaluation disclosed a spontaneous cervicocephalic dissection of the right internal carotid artery with infarction of the anterior ...
openaire   +2 more sources