Results 91 to 100 of about 176,284 (162)

Involvement of the Ubiquitin-Proteasome System in the Early Stages of Wallerian Degeneration [PDF]

, 2003
Local axon degeneration is a common pathological feature of many neurodegenerative diseases and peripheral neuropathies. While it is believed to operate with an apoptosis-independent molecular program, the underlying molecular mechanisms are largely ...
Hoopfer, Eric, Watts, Ryan, Zhai, Qiwei, Kim, Anna, Mitchison, Timothy, Luo, Liqun, He, Zhigang, Liu, Qing, Wang, Jing   +8 more
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NMNAT Proteins that Limit Wallerian Degeneration Also Regulate Critical Period Plasticity in the Visual Cortex [PDF]

, 2019
Many brain regions go through critical periods of development during which plasticity is enhanced. These critical periods are associated with extensive growth and retraction of thalamocortical and intracortical axons.
Levelt, Christiaan N, Saiepour, M Hadi, Kamphuis, Willem, Saiepour, M. Hadi, Heime, J. Alexander, Krimpenfort, Roos, Levelt, Christiaan N., van Lier, Mariska, Smit-Rigter, Laura, Ruimschotel, Emma, Heimel, J Alexander   +10 more
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Retrograde and Wallerian Axonal Degeneration Occur Synchronously after Retinal Ganglion Cell Axotomy [PDF]

, 2012
Axonal injury and degeneration are pivotal pathological events in diseases of the nervous system. In the past decade, it has been recognized that the process of axonal degeneration is distinct from somal degeneration and that axoprotective strategies may
Levin, Leonard A., Costantino, Santiago, Catrinescu, Maria-Magdalena, Belisle, Jonathan M., Kanamori, Akiyasu   +4 more
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The involvement of Phospholipase, A2 in Wallerian degeneration /

, 1999
Phospholipase A2 (PLA2) enzymes target membrane phospholipids to liberate free fatty acids, such as arachidonic acid, a precursor of inflammatory mediators, as well as lysophospholipids which disrupt membrane structure.
De, Susna R.
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Intra-axonal calcium changes after axotomy in wild-type and slow Wallerian degeneration axons

, 2012
Calcium accumulation induces the breakdown of cytoskeleton and axonal fragmentation in the late stages of Wallerian degeneration. In the early stages there is no evidence for any long-lasting, extensive increase in intra-axonal calcium but there does ...
Conforti, L., Siklos, L., Bootman, Martin, Siklós, L, Adalbert, R., Coleman, M. P., Walker, S.A., Coleman, M.P., Walker, S. A., Roderick, H. L., Morreale, G., Bootman, M.D., Paizs, M., Roderick, H. Llewelyn   +13 more
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Specific phospholipid scramblases are involved in exposure of phosphatidylserine, an “eat-me” signal for phagocytes, on degenerating axons

Communicative & Integrative Biology, 2017
Axonal degeneration is a key pathological feature of several neurological disorders. Emerging evidence has suggested a pathological connection between axonal degeneration and autophagy, a lysosomal degradation pathway.
Shuji Wakatsuki, Toshiyuki Araki
doaj   +1 more source

Wallerian degeneration : a major component of early axonal pathology in multiple sclerosis

, 2010
Axonal loss is a major component of the pathology of multiple sclerosis (MS) and the morphological basis of permanent clinical disability. It occurs in demyelinating plaques but also in the so-called normal-appearing white matter (NAWM).
Mueller, Sven, Metz, Imke, Dallenga, Tobias, Brück, Wolfgang, König, Fatima Barbara, Koenig, Fatima Barbara, Brueck, Wolfgang, Müller, Sven, Stadelmann, Christine, Dziedzic, Tomasz   +9 more
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Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1 and interleukin-1 in Wallerian degeneration

, 2005
International audienceWallerian degeneration in the CNS and PNS consists of degradation and phagocytosis of axons and their myelin sheath distal to the site of injury.
Perrin, Florence,, Perrin, Florence, E., Lacroix, Steve, Avilés-Trigueros, Marcelino, David, Samuel   +4 more
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Highly Bioadaptable Hybrid Conduits with Spatially Bidirectional Structure for Precision Nerve Fiber Regeneration via Gene Therapy

Advanced Science
Peripheral nerve deficits give rise to motor and sensory impairments within the limb. The clinical restoration of extensive segmental nerve defects through autologous nerve transplantation often encounters challenges such as axonal mismatch and ...
Renliang Zhao, Xiangtian Deng, Jizhao Dong, Chen Liang, Xiaozhong Yang, Yunfeng Tang, Juan Du, Zilu Ge, Dong Wang, Yifan Shen, Lianghua Jiang, Wei Lin, Tonghe Zhu, Guanglin Wang   +13 more
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Wallerian degeneration, left corticospinal tract from right hemisphere infarct

, 1997
Wallerian degeneration, left corticospinal tract from right hemisphere infarct. Transverse plane.

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