Results 151 to 160 of about 168,621 (384)

Disintegration of the KITENIN/ErbB4 Functional Complex by the Flavonoid Hispidulin Suppresses Colorectal Cancer Progression

open access: yesAdvanced Therapeutics, EarlyView.
Hispidulin disrupts the KITENIN/ErbB4 oncogenic complex and inhibits KITENIN‐mediated AP‐1 activity, cell invasion, and aerobic glycolysis. It also suppresses the production of cancer‐associated metabolites and downregulates transcriptional regulators downstream of the KITENIN complex.
Mücahit Varlı   +7 more
wiley   +1 more source

Modeling the Diffusion Coefficient of Charge Carriers in Metal Ion Batteries using the Randles‐Sevcik Equation

open access: yesAdvanced Theory and Simulations, EarlyView.
The development of multivalent rechargeable batteries (MRB) requires the prediction of battery behavior at experimentally unreached conditions in the laboratory. Therefore, the diffusion equation is used to analyze the relation between the diffusion coefficient (DC) and the Warburg factor for different MRBs to predict the theoretical DC values at ...
Eman I. Abd El‐Latif   +6 more
wiley   +1 more source

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3‐Regulated HIF1A/HMOX1 Signaling Pathway

open access: yesAdvanced Science, EarlyView.
This study reveals that histone lactylation, a modification derived from lactate, plays a crucial role in ferroptosis resistance in ectopic endometrial stromal cells. This resistance is mediated via the HIF1A/HMOX1 pathway regulated by METTL3. In vivo, a combination of 2‐DG and erastin shows promise as an effective treatment for endometriosis ...
Zongwen Liang   +8 more
wiley   +1 more source

METTL14‐Mediated M6A Modification of LINC01094 Induces Glucose Metabolic Reprogramming in Breast Cancer by Recruiting the PKM2/JMJD5 Complex

open access: yesAdvanced Science, EarlyView.
METTL14/IGF2BP2‐mediated m6A modification drives LINC01094 upregulation in BC. Then, LINC01094 interacts with PKM2 monomers to promote their dimerization, while serving as a flexible scaffold to facilitate the assembly of the PKM2/JMJD5 complex, synergistically stabilizing PKM2 dimers and enhancing their nuclear translocation.
Mengqi Wang   +8 more
wiley   +1 more source

Nondestructive evaluation techniques for nickel-cadmium aerospace battery cells [PDF]

open access: yes
The ac impedance characteristics of Ni-Cd cells as an in-situ, nondestructive means of determining cell lifetime, particularly with respect to the probability of premature failure were evaluated.
Haak, R., Tench, D.
core   +1 more source

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang   +16 more
wiley   +1 more source

Reviewing the structure and function of the scorpion's hepatopancreas [PDF]

open access: yesArthropods, 2012
During a long-terms study of scorpions, it was possible to follow changes taking place in the mass, water and lipid content of the hepatopancreas in freshly caught Scorpio maurus fuscus.
M.R. Warburg
doaj  

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