Results 151 to 160 of about 157,233 (338)

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

open access: yesAdvanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji   +14 more
wiley   +1 more source

CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation

open access: yesAdvanced Science, EarlyView.
Cell proliferation requires the integration of cell cycle and anabolic signals. G1‐phase regulator CDH1 coordinates anabolism through the CDH1‐VHL‐AARS2/HIF1α axis, while CDH1‐accumulated R5P is sensed by TKTL1 to facilitate CDH1 degradation and cell cycle initiation, constituting a CDH1‐centered regulatory circuit.
Yun‐Zi Mao   +18 more
wiley   +1 more source

Medium‐Entropy Engineering Enhances Na⁺/Electron Transport in Na3Fe0.1Mn0.2Co0.2Ni0.3V1.2(PO4)2F3@CNTs Cathode for Sodium‐Ion Batteries

open access: yesAdvanced Science, EarlyView.
This study proposes a medium‐entropy strategy to enhance sodium vanadium fluorophosphate cathodes. The designed Na3Fe0.1Mn0.2Co0.2Ni0.3V1.2(PO4)2F3@CNTs composite enhances structural stability and charge transport. Entropy‐induced distortion and carbon nanotubes (CNTs) synergistically improve Na⁺/electron kinetics. In situ XRD reveals a reversible dual‐
Ju Yang   +7 more
wiley   +1 more source

Engineering Bacteria as Living Therapeutics in Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen   +6 more
wiley   +1 more source

A homozygous nonsense mutation in the Fukutin gene causes a Walker-Warburg syndrome phenotype [PDF]

open access: bronze, 2003
Daniel Beltrán Valero de Bernabé   +11 more
openalex   +1 more source

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