Results 151 to 160 of about 678,174 (319)

A New Target for Hepatic Fibrosis Prevention and Treatment: The Warburg Effect

Frontiers in Bioscience-Landmark
Hepatic fibrosis is a major public health problem that endangers human wellbeing. In recent years, a number of studies have revealed the important impact of metabolic reprogramming on the occurrence and development of hepatic fibrosis.
Meng Pan, Huanyu Li, Xiaoyan Shi
doaj   +1 more source

PKM2 promotes reductive glutamine metabolism

Cancer Biology & Medicine, 2018
Objective: Pyruvate kinases M (PKM), including the PKM1 and PKM2 isoforms, are critical factors in glucose metabolism. PKM2 promotes aerobic glycolysis, a phenomenon known as “the Warburg effect”.
Miao Liu, Yuanyuan Wang, Yuxia Ruan, Changsen Bai, Li Qiu, Yanfen Cui, Guoguang Ying, Binghui Li   +7 more
doaj   +1 more source

The Novel Dual GIP and GLP‐1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism

Advanced Science, EarlyView.
Tirzepatide, a dual GIP/GLP‐1 receptor agonist for diabetes, suppresses colorectal cancer growth by targeting glucose metabolism. It inhibits cancer cell proliferation, promotes apoptosis, and induces tumor regression. It reduces glucose uptake and destabilizes HIF‐1α for degradation to downregulate PFKFB3/PFK‐1 enzymes, thus contributing to the ...
Yikai Zhang, Yi Xie, Shenglong Xia, Xinnuo Ge, Jiaying Li, Fang Liu, Fan Jia, Shengyao Wang, Qiao Zhou, Menghan Gao, Weihuan Fang, Chao Zheng   +11 more
wiley   +1 more source

Zonated Copper‐Driven Breast Cancer Progression Countered by a Copper‐Depleting Nanoagent for Immune and Metabolic Reprogramming

Advanced Science, EarlyView.
Spatially resolved multiomics reveals that high‐copper zones are closely associated with tumor metastasis, immune‐desert phenotypes, and oxidative‐phosphorylation (OXPHOS)‐dependent proliferation. A targeted bacterial nanovesicle delivering copper‐depleting agents effectively reduces tumor copper levels, inhibits OXPHOS‐dependent tumor growth, and ...
Lin Chen, Saibo Ma, Hao Wu, Lingna Zheng, Yunpeng Yi, Guangnian Liu, Baoyi Li, Jiayi Sun, Yang Du, Bing Wang, Yike Liu, Cheng Zhang, Jing Chang, Yuheng Pang, Wenjing Wang, Meng Wang, Motao Zhu   +16 more
wiley   +1 more source

Tumoroid Model Reveals Synergistic Impairment of Metabolism by Iron Chelators and Temozolomide in Chemo‐Resistant Patient‐derived Glioblastoma Cells

Advanced Science, EarlyView.
This study investigates the metabolic vulnerabilities of glioblastoma (GBM), an aggressive brain tumor. Research demonstrates that iron chelation therapy, in combination with standard chemotherapy, significantly enhances the efficacy of treatment against resistant GBM cells in a 3D tumoroid model.
Meitham Amereh, Amir Seyfoori, Shahla Shojaei, Sarah Lane, Tian Zhao, Mahdieh Shokrollahi Barough, Julian J. Lum, Patrick Walter, Mohsen Akbari   +8 more
wiley   +1 more source

Hippocampal warburg effect mediates hydrogen sulfide-ameliorated diabetes-associated cognitive dysfunction: Involving promotion of hippocampal synaptic plasticity

Neuroscience Research
Our previous studies have reported that hydrogen sulfide (H2S) has ability to improve diabetes-associated cognitive dysfunction (DACD), but the exact mechanisms remain unknown.
Run-Qi Li, Wei-Wen Zhu, Cheng Li, Ke-Bin Zhan, Ping Zhang, Fan Xiao, Jia-Mei Jiang, Wei Zou   +7 more
doaj  

Cancer metabolism: The Warburg effect today

Experimental and Molecular Pathology, 2010
One of the first studies on the energy metabolism of a tumour was carried out, in 1922, in the laboratory of Otto Warburg. He established that cancer cells exhibited a specific metabolic pattern, characterized by a shift from respiration to fermentation, which has been later named the Warburg effect.
openaire   +2 more sources

An analysis of the Brown-Biefeld effect

, 2012
When a high voltage is applied on an asymmetric capacitor, it experiences a force acting toward its thinner electrode. This effect is called Brown-Biefeld effect (BB), after its discoverers Thomas-Townsend Brown and Paul-Alfred Biefeld.
Amoruso, Bahder, Bouziane, Bouziane, Chen, Daniela Sohar, Davies, Deutsch, Felici, Feng, Goldman, Ieta, Jones, Jones, Kaptzov, Kondo, Moshe Mudrik, Musha, Peek, Popkov, Reuven Ianconescu, Sarma, Selim, Selim, Sigmond, Sigmond, Tajmar, Tajmar, Townsend, Tsyrlin, Warburg, Warburg, Zhao, Zhao   +33 more
core   +1 more source

SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling

Advanced Science, EarlyView.
As a downstream target of α2δ1‐mediated calcium signaling, SIRT4 serves as an oncogene to promote the stemness of pancreatic cancer via deacetylating ENO1 directly at K358, leading to attenuated ENO1's RNA‐binding capacity, enhanced glycolytic substrate 2‐PG binding and robust glycolytic activity to increase the level of lactate that induce histone ...
Mengzhu Lv, Xiaodan Yang, Congcong Xu, Qingru Song, Hailian Zhao, Tianjiao Sun, Jingtao Liu, Yuan Zhang, Guogui Sun, Yuanchao Xue, Zhiqian Zhang   +10 more
wiley   +1 more source

Construction of Protein‐Like Helical‐Entangled Structure in Lithium‐Ion Silicon Anode Binders via Helical Recombination and Hofmeister Effect

Advanced Science, EarlyView.
This study presents a gelatin‐xanthan gum composite binder featuring a protein‐like helical‐entangled structure, formed through thermo‐responsive recombination and the Hofmeister effect. This innovative structure, akin to protein behavior, absorbs stress and strain, thereby enhancing the cycling stability and rate performance of silicon anodes in ...
Shiyuan Dai, Fei Huang, Jinglun Yan, Yuan Yuan Sun, Chao Chen, HaiDong Li   +5 more
wiley   +1 more source