Results 151 to 160 of about 108,453 (351)

Warburg effect-promoted exosomal circ_0072083 releasing up-regulates NANGO expression through multiple pathways and enhances temozolomide resistance in glioma [PDF]

, 2021
Chenyu Ding, Xuehan Yi, Xiangrong Chen, Zanyi Wu, Honghai You, Xiaoyong Chen, Gaoqi Zhang, Yong Sun, Xingyao Bu, Xiyue Wu, Zhangya Lin, Jianjun Gu, Yuanxiang Lin, Dezhi Kang   +13 more
openalex   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Regulation of Eukaryote Metabolism: An Abstract Model Explaining the Warburg/Crabtree Effect [PDF]

, 2021
Laetitia Gibart, Rajeev Khoodeeram, Gilles Bernot, Jean‐Paul Comet, Jean‐Yves Trosset   +4 more
openalex   +1 more source

Mitigating the Rock‐Salt Phase Transformation in Disordered LNMO Through Synergetic Solid‐State AlF3/LiF Modifications

Advanced Science, EarlyView.
The transition between the spinel and rock‐salt phases induces irreversible structural changes in disordered LiNi0.5Mn1.5O4, thereby preventing it from fully releasing its electrochemical capacity during charge/discharge cycling. Abstract High‐voltage disordered spinel LiNi0.5Mn1.5O4 is a promising cathode material for high power density in lithium‐ion
Xingqi Chang, Carlos Escudero, Ashley P Black, Sharona Horta, Elías Martínez, Xuan Lu, Jordi Llorca, Maria Ibáñez, Jordi Jacas Biendicho, Andreu Cabot   +9 more
wiley   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Nanodiamond Regulated Electrolyte Enhances Thermal, Chemical and Structural Properties for Highly Reversible Zn Metal Anodes

Advanced Science, EarlyView.
Nanodiamond additives are dispersed in the aqueous electrolyte to organize water molecules, suppress gas evolution and metal corrosion, and guide zinc to deposit more uniformly. Together with enhanced thermal conductivity for fast heat removal, this strategy reduces temperature rise and degradation, enabling safer, more durable rechargeable zinc metal ...
Jiayan Zhu, Xuan Gao, Nan Gao, Shaoheng Cheng, Junsong Liu, Yuhang Dai, Zhengxiao Guo, Hongdong Li   +7 more
wiley   +1 more source

Mussel‐Bioinspired Edible Ca2+‐Crosslinked Alginate Hydrogel Electrodes for Glucose Gastrointestinal Monitoring

Advanced Science, EarlyView.
A fully edible soft electrode is engineered from Ca2⁺‐crosslinked alginate integrated with polydopamine, silver nanoparticles, and food‐grade glucose oxidase. The hybrid hydrogel combines ionic and electronic conduction, enabling efficient glucose‐to‐H2O2 conversion and catalytic reduction in simulated intestinal fluid.
Verdiana Marchianò, Claudio Pellegrini, Angelo Tricase, Eleonora Macchia, Andrea Brattelli, Luigi Gentile, Patrizia Nadia Hanieh, Noemi Fiaschini, Antonio Rinaldi, Luisa Torsi, Paolo Bollella   +10 more
wiley   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Achieving Fast Charging and Superior Cycling Stability Single‐Crystal Ni‐Rich Cathodes by Ultrafast Aqueous Washing

Advanced Science, EarlyView.
Prolonged water washing severely damages the surface layered structure of single‐crystal Ni‐rich cathodes, forming a thick rock‐salt barrier. In contrast, our 3‐min ultrafast washing removes residual lithium while confining surface reconstruction to an ultrathin 2–4 nm layer, thereby unlocking excellent fast‐charging and cycling stability.
Kaixin Liu, Jia Yang, Huaping Wang, Yongtao Tan, Dongdong Fan, Yongjian Cui, YunJian Liu, Xiaoyan Li, Hailong Wang   +8 more
wiley   +1 more source

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source