Results 131 to 140 of about 53,264 (296)
Erastin-like anti-Warburg compounds X1 and X4 are GLS2-selective covalent glutaminase inhibitors
The Warburg effect is a metabolic alteration in cancer cells characterized by aerobic glycolysis and lactate production. A recent phenotypic screen for compounds that reverse Warburg metabolism identified two compounds, X1 and X4, that restore the ...
Morgan, Miele +5 more
core +1 more source
CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction
Advanced Science, EarlyView.CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma +12 more
wiley +1 more source
Impedance of Nonelectroneutral Solid Electrolyte Interphases With Nanopores: A Theoretical Model
Advanced Science, EarlyView.Physical modeling reveals that often‐neglected non‐electroneutrality and nanopores in the solid‐electrolyte interphase (SEI) govern the impedance behavior. Under nonreactive conditions, the low‐frequency constant‐phase element (CPE) phenomenon can be attributed to the nonelectroneutral local conditions in the SEI.
Chenkun Li, Jun Huang
wiley +1 more source
Advanced Science, EarlyView.Impurity tolerance in LiFePO4 cathodes varies strongly with impurity type and content. Low Ni levels are accommodated within the lattice with minimal structural disruption, whereas higher Ni contents introduce antisite disorder. In contrast, Cr impurities segregate from the LiFePO4 framework, blocking lithium‐ion pathways and leading to inferior ...
Minjin Kim +3 more
wiley +1 more source
Warburg effect in queens with mammary tumors
, 2018 Over the last years, pets’ life expectancy increased, and neoplasm became a leading cause of death. Mammary tumors are among the most frequent neoplasias in felines.
de Almeida, Melissa Isabelle Martinho
core
High Fracture Toughness of 1D Copper‐Based MOP Electrode Enables Fast‐Charging Lithium‐Ion Batteries
Advanced Science, EarlyView.Traditional electrode materials suffer from particle cracking and rapid capacity fade during fast charging, largely originating from their low fracture toughness. This work introduces a one‐dimensional Cu‐based metal–organic polymer, in which strong π‐d conjugation and π–π stacking endow the framework with high fracture toughness, simultaneously ...
Mingli Li +8 more
wiley +1 more source
Warburg Effect: Aerobic Glycolysis During Mammalian Reproduction
, 2015 糖代谢是生物体赖以生存的基本生化过程之一.哺乳动物体内不同细胞对葡萄糖的利用方式不同.摄氧充足时,细胞通过氧化磷酸化在线粒体中进行有氧呼吸;缺氧的细胞则选择抑制氧化磷酸化,通过糖酵解产生乳酸.但有些细胞在有氧条件下也能进行糖酵解,从而产生大量的乳酸,这种糖酵解途径称为瓦氏效应.以前认为瓦氏效应主要存在于肿瘤细胞中,但近来发现在哺乳动物的生殖过程中也存在瓦氏效应.本文综述了哺乳动物生殖发育过程的瓦氏效应及其与一些生殖疾病的关系.Glucose metabolism is one of essential ...
杨增明, 左茹娟
core
Advanced Science, EarlyView.K+ pre‐intercalation in V2O5·nH2O induces interlayer contraction, oxygen‐vacancy formation, and mixed‐valence states, activating defect‐mediated proton‐dominated transport. This enables cooperative H+/Zn2+ storage with enhanced kinetics and stability. The resulting Zn‐based thin‐film and microbatteries deliver high areal energy and capacity, offering a
Jingli Luo +14 more
wiley +1 more source
, 2019 The Warburg effect is a peculiar feature of cancer’s metabolism, which is an attractive therapeutic target that could aim tumor cells while sparing normal tissue.
Yurou Xie (8054852) +14 more
core +1 more source
Advanced Science, EarlyView.This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan +6 more
wiley +1 more source