Results 1 to 10 of about 49,082 (163)
Partners in the Warburg effect [PDF]
eLife, 2016 Cells that surround tumors produce vesicles that supply nutrients to cancer cells and, more surprisingly, also impair the generation of energy in these cancer cells.
Joshua D Rabinowitz, Hilary A Coller
doaj +4 more sources
Protein networks linking Warburg and reverse Warburg effects to cancer cell metabolism [PDF]
BioFactors, 2021 AbstractIt was 80 years after the Otto Warburg discovery of aerobic glycolysis, a major hallmark in the understanding of cancer. The Warburg effect is the preference of cancer cell for glycolysis that produces lactate even when sufficient oxygen is provided.
Dina Johar +2 more
exaly +4 more sources
Acta Pharmaceutica Sinica BCancer reprogramming is an important facilitator of cancer development and survival, with tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation, even under sufficient oxygen supply condition.
Minru Liao, Dahong Yao, Zhiwen Wang
exaly +3 more sources
Vitamin D promotes apoptosis and enhances cisplatin sensitivity in bladder cancer cells by inhibiting the Warburg effect through the AKT/mTOR pathway [PDF]
BMC UrologyObjective Patients with bladder cancer (BCa) have a poor prognosis and are prone to metastasis. Deficiency of 1,25-dihydroxyvitamin D3 (VD) is associated with increased incidence and decreased survival in various tumors.
Jian Zhou +5 more
doaj +2 more sources
ADAPTOR PROTEIN RUK/CIN85 IS INVOLVED IN THE GLUCOSE METABOLISM REPROGRAMMING IN BREAST CANCER CELLS [PDF]
Biotechnologia Acta, 2022 Aim. This study aimed to investigate the changes in glucose metabolism in mouse 4T1 breast adenocarcinoma cells with different levels of Ruk/CIN85 expression. Methods.
M. I. Bekala +7 more
doaj +1 more source
Autophagy, Warburg, and Warburg Reverse Effects in Human Cancer [PDF]
BioMed Research International, 2014 Autophagy is a highly regulated-cell pathway for degrading long-lived proteins as well as for clearing cytoplasmic organelles. Autophagy is a key contributor to cellular homeostasis and metabolism. Warburg hypothesized that cancer growth is frequently associated with a deviation of a set of energy generation mechanisms to a nonoxidative breakdown of ...
González, Claudio Daniel +5 more
openaire +4 more sources
Iron Regulates the Warburg Effect and Ferroptosis in Colorectal Cancer
Frontiers in Oncology, 2021 Iron promotes the proliferation of cancer cells, but it also contributes to cell death. Here we explored whether iron could promote the Warburg effect of colorectal cancer (CRC) cells and suppress sensitivity to ferroptosis by inducing reactive oxygen ...
Yin Yuan +6 more
doaj +1 more source
Fructose in the kidney: from physiology to pathology [PDF]
Kidney Research and Clinical Practice, 2021 The Warburg effect is a unique property of cancer cells, in which glycolysis is activated instead of mitochondrial respiration despite oxygen availability.
Takahiko Nakagawa, Duk-Hee Kang
doaj +1 more source
Cancer Medicine, 2023 Background Glioblastoma (GBM), the most common primary malignant brain tumor, has a poor prognosis, with a median survival of only 14.6 months.
Rong Zhang +9 more
doaj +1 more source
The Warburg effect: 80 years on [PDF]
Biochemical Society Transactions, 2016 Influential research by Warburg and Cori in the 1920s ignited interest in how cancer cells' energy generation is different from that of normal cells. They observed high glucose consumption and large amounts of lactate excretion from cancer cells compared with normal cells, which oxidised glucose using mitochondria.
Morten, K, Potter, M, Newport, E
openaire +3 more sources