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The epigenetic basis of the Warburg effect [PDF]
Epigenetics, 2010 Cancer development results from the accumulation of genetic and epigenetic changes. By interacting with intracellular signaling to promote carcinogenesis, epigenetic networks can actively transform cancer-promoting signals from tumor-permissive microenvironment to coordinate cellular proliferation and metabolism in the initiation and progression of ...
Xian, Wang, Hongchuan, Jin
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The Warburg effect and drug resistance [PDF]
British Journal of Pharmacology, 2016 The Warburg effect describes the increased utilization of glycolysis rather than oxidative phosphorylation by tumour cells for their energy requirements under physiological oxygen conditions. This effect has been the basis for much speculation on the survival advantage of tumour cells, tumourigenesis and the microenvironment of tumours. More recently,
Bhattacharya, Bhaskar +2 more
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The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer
Frontiers in Oncology, 2020 As shown in our previous study, SIRT6 promotes an aggressive phenotype and the epithelial-mesenchymal transition (EMT) in papillary thyroid cancer (PTC). In this study, we focused on the regulatory axis including SIRT6, autophagy, and the Warburg effect.
Zhou Yang +5 more
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Revisiting the Warburg Effect with Focus on Lactate
Cancers, 2022 Rewired metabolism is acknowledged as one of the drivers of tumor growth. As a result, aerobic glycolysis, or the Warburg effect, is a feature of many cancers. Increased glucose uptake and glycolysis provide intermediates for anabolic reactions necessary for cancer cell proliferation while contributing sufficient energy.
Eva Kocianova +2 more
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Frontiers in Oncology, 2022 Tumor radiation resistance along with chemotherapy resistance is one of the main causes of therapeutic failure of radiotherapy-treated head and neck cancers.
Camil Ciprian Mireștean +5 more
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PLoS ONE, 2019 The Warburg Effect has emerged as a potential drug target because, in some cancer cell lines, it is sufficient to subvert it in order to kill cancer cells.
Philemon Ubanako +2 more
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Journal of Experimental & Clinical Cancer Research, 2023 Background The Warburg effect is well-established to be essential for tumor progression and accounts for the poor clinical outcomes of hepatocellular carcinoma (HCC) patients.
Jun Zheng +16 more
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Nuclear receptors and the
International Journal of Cancer, 2014 In 1927 Otto Warburg established that tumours derive energy primarily from the conversion of glucose to lactic acid and only partially through cellular respiration involving oxygen. In the 1950s he proposed that all causes of cancer reflected different mechanisms of disabling cellular respiration in favour of fermentation (now termed aerobic glycolysis)
Thorne, JL, Campbell, MJ
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Relevance of the Warburg Effect in Tuberculosis for Host-Directed Therapy
Frontiers in Cellular and Infection Microbiology, 2020 Tuberculosis (TB) was responsible for more deaths in 2019 than any other infectious agent. This epidemic is exacerbated by the ongoing development of multi-drug resistance and HIV co-infection.
Bridgette M. Cumming +4 more
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Cell Death and Disease, 2021 Hypoxic microenvironment is common in solid tumors, particularly in pancreatic ductal adenocarcinoma (PDAC). The Warburg effect is known to facilitate cancer aggressiveness and has long been linked to hypoxia, yet the underlying mechanism remains largely
Rongkun Li +11 more
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