Results 21 to 30 of about 53,058 (296)
Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect [PDF]
, 2011 The Warburg effect - a classical hallmark of cancer metabolism - is a counter-intuitive phenomenon in which rapidly proliferating cancer cells resort to inefficient ATP production via glycolysis leading to lactate secretion, instead of relying primarily ...
Tomer Shlomi +14 more
core +1 more source
The Warburg effect and drug resistance [PDF]
British Journal of Pharmacology, 2016 The Warburg effect describes the increased utilization of glycolysis rather than oxidative phosphorylation by tumour cells for their energy requirements under physiological oxygen conditions. This effect has been the basis for much speculation on the survival advantage of tumour cells, tumourigenesis and the microenvironment of tumours. More recently,
Bhattacharya, Bhaskar +2 more
openaire +2 more sources
Cellular Physiology and Biochemistry, 2017 Background/Aims: The enhanced proliferation of pulmonary arterial smooth muscle cells (PASMCs) is a central pathological component in pulmonary arterial hypertension (PAH).
Yunbin Xiao +9 more
doaj +1 more source
The epigenetic basis of the Warburg effect [PDF]
Epigenetics, 2010 Cancer development results from the accumulation of genetic and epigenetic changes. By interacting with intracellular signaling to promote carcinogenesis, epigenetic networks can actively transform cancer-promoting signals from tumor-permissive microenvironment to coordinate cellular proliferation and metabolism in the initiation and progression of ...
Xian, Wang, Hongchuan, Jin
openaire +2 more sources
Expression of proteins associated with the Warburg‐effect and survival in colorectal cancer
The Journal of Pathology: Clinical Research, 2022 Previous research has suggested that the expression of proteins related to the Warburg effect may have prognostic value in colorectal cancer (CRC), but results remain inconsistent.
Kelly Offermans +9 more
doaj +1 more source
The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer
Frontiers in Oncology, 2020 As shown in our previous study, SIRT6 promotes an aggressive phenotype and the epithelial-mesenchymal transition (EMT) in papillary thyroid cancer (PTC). In this study, we focused on the regulatory axis including SIRT6, autophagy, and the Warburg effect.
Zhou Yang +5 more
doaj +1 more source
Revisiting the Warburg Effect with Focus on Lactate
Cancers, 2022 Rewired metabolism is acknowledged as one of the drivers of tumor growth. As a result, aerobic glycolysis, or the Warburg effect, is a feature of many cancers. Increased glucose uptake and glycolysis provide intermediates for anabolic reactions necessary for cancer cell proliferation while contributing sufficient energy.
Eva Kocianova +2 more
openaire +2 more sources
Frontiers in Oncology, 2022 Tumor radiation resistance along with chemotherapy resistance is one of the main causes of therapeutic failure of radiotherapy-treated head and neck cancers.
Camil Ciprian Mireștean +5 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2023 Background The Warburg effect is well-established to be essential for tumor progression and accounts for the poor clinical outcomes of hepatocellular carcinoma (HCC) patients.
Jun Zheng +16 more
doaj +1 more source
Nuclear receptors and the
International Journal of Cancer, 2014 In 1927 Otto Warburg established that tumours derive energy primarily from the conversion of glucose to lactic acid and only partially through cellular respiration involving oxygen. In the 1950s he proposed that all causes of cancer reflected different mechanisms of disabling cellular respiration in favour of fermentation (now termed aerobic glycolysis)
Thorne, JL, Campbell, MJ
openaire +3 more sources