Results 11 to 20 of about 53,058 (296)

Mechanism of Warburg Effect and Its Effect on Tumor Metastasis

Chinese Journal of Lung Cancer, 2015
Cancer cells exhibit altered glucose metabolism characterized by a preference for aerobic glycolysis even when the oxygen content is normal, a phenomenon termed “Warburg effect”. However the definite molecular mechanisms of Warburg effect remains unclear,
Huijun WEI, Lili GUO, Lin LI, Qinghua ZHOU, Zhihao WU   +4 more
doaj   +2 more sources

Reversing the Warburg Effect as a Treatment for Glioblastoma [PDF]

Journal of Biological Chemistry, 2013
Glioblastoma multiforme (GBM), like most cancers, possesses a unique bioenergetic state of aerobic glycolysis known as the Warburg effect. Here, we documented that methylene blue (MB) reverses the Warburg effect evidenced by the increasing of oxygen consumption and reduction of lactate production in GBM cell lines.
Ethan, Poteet, Gourav Roy, Choudhury, Ali, Winters, Wenjun, Li, Myoung-Gwi, Ryou, Ran, Liu, Lin, Tang, Anuja, Ghorpade, Yi, Wen, Fang, Yuan, Stephen T, Keir, Hai, Yan, Darell D, Bigner, James W, Simpkins, Shao-Hua, Yang   +14 more
openaire   +3 more sources

Anti-Warburg effect of rosmarinic acid via miR-155 in gastric cancer cells

Drug Design, Development and Therapy, 2015
Shuai Han,* Shaohua Yang,* Zhai Cai, Dongyue Pan, Zhou Li, Zonghai Huang, Pusheng Zhang, Huijuan Zhu, Lijun Lei, Weiwei Wang Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China ...
Han S, Yang SH, Cai Z, Pan DY, Li Z, Huang ZH, Zhang PS, Zhu HJ, Lei LJ, Wang WW   +9 more
doaj   +1 more source

LPS induces inflammatory chemokines via TLR-4 signalling and enhances the Warburg Effect in THP-1 cells.

PLoS ONE, 2019
The Warburg Effect has emerged as a potential drug target because, in some cancer cell lines, it is sufficient to subvert it in order to kill cancer cells.
Philemon Ubanako, Ntombikayise Xelwa, Monde Ntwasa   +2 more
doaj   +2 more sources

Tyrosine Kinase Signaling in Cancer Metabolism: PKM2 Paradox in the Warburg Effect [PDF]

Frontiers in Cell and Developmental Biology, 2018
The Warburg Effect, or aerobic glycolysis, is one of the major metabolic alterations observed in cancer. Hypothesized to increase a cell's proliferative capacity via regenerating NAD+, increasing the pool of glycolytic biosynthetic intermediates, and ...
Elizabeth K. Wiese, Elizabeth K. Wiese, Taro Hitosugi, Taro Hitosugi   +3 more
doaj   +2 more sources

Multi-scale computational study of the Warburg effect, reverse Warburg effect and glutamine addiction in solid tumors.

PLoS Computational Biology, 2018
Cancer metabolism has received renewed interest as a potential target for cancer therapy. In this study, we use a multi-scale modeling approach to interrogate the implications of three metabolic scenarios of potential clinical relevance: the Warburg ...
Mengrou Shan, David Dai, Arunodai Vudem, Jeffrey D Varner, Abraham D Stroock   +4 more
doaj   +2 more sources

Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications

Journal of Hematology & Oncology, 2022
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death worldwide. Countless CRC patients undergo disease progression.
Xinyang Zhong, Xuefeng He, Yaxian Wang, Zijuan Hu, Huixia Huang, Senlin Zhao, Ping Wei, Dawei Li   +7 more
doaj   +1 more source

Research Progress on Regulatory Mechanism of Ubiquitin Modification on Warburg Effect in Malignant Tumors

Zhongliu Fangzhi Yanjiu, 2022
Ubiquitin modification and Warburg effect play an important role in the occurrence and development of tumors. The process of tumor ubiquitin modification is closely related to glycolysis, that is, ubiquitin modification in tumor cells can regulate the ...
WANG Fengli, HU Jing
doaj   +1 more source

Hydrogen Sulfide Ameliorates Angiotensin II-Induced Atrial Fibrosis Progression to Atrial Fibrillation Through Inhibition of the Warburg Effect and Endoplasmic Reticulum Stress

Frontiers in Pharmacology, 2021
Atrial fibrosis is the basis for the occurrence and development of atrial fibrillation (AF) and is closely related to the Warburg effect, endoplasmic reticulum stress (ERS) and mitochondrion dysfunctions-induced cardiomyocyte apoptosis. Hydrogen sulfide (
Heng-Jing Hu, Heng-Jing Hu, Xiu-Heng Wang, Yao Liu, Tian-Qing Zhang, Zheng-Rong Chen, Chi Zhang, Zhi-Han Tang, Shun-Lin Qu, Hui-Fang Tang, Zhi-Sheng Jiang, Zhi-Sheng Jiang, Zhi-Sheng Jiang   +12 more
doaj   +1 more source

PKM2 promotes reductive glutamine metabolism

Cancer Biology & Medicine, 2018
Objective: Pyruvate kinases M (PKM), including the PKM1 and PKM2 isoforms, are critical factors in glucose metabolism. PKM2 promotes aerobic glycolysis, a phenomenon known as “the Warburg effect”.
Miao Liu, Yuanyuan Wang, Yuxia Ruan, Changsen Bai, Li Qiu, Yanfen Cui, Guoguang Ying, Binghui Li   +7 more
doaj   +1 more source