Results 121 to 130 of about 9,923,041 (290)

Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer

Advanced Science, EarlyView.
Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.
Meng Qian, Tongguan Tian, Zhenxiang Wang, Huihui Sun, Ming Zong, Ying Chen, Jie Xiong, Ye Chen, Zhiqian Hu, Tianming Li, Yanping Xu, Shuchang Xu   +11 more
wiley   +1 more source

Linkage Engineering Boosts Battery Performance of Two‐Electron Phenothiazine‐Based Polyamide Cathodes

Advanced Science, EarlyView.
Three phenothiazine‐based polyamides featuring gradually strengthened electron‐withdrawing linkers are developed as high‐voltage cathodes for lithium‐organic batteries. The linker motif serves not only as a structural bridge to suppress solubility, but also as a functional design element that governs optoelectronic properties and electron/ion transport
Shujuan Cao, Chunping Ren, Jing Qin, Xiujuan Wang, Xiaoming He   +4 more
wiley   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Heterointerface Seeding Accelerates Bi0/Bi3+ Phase Conversion for Ultrafast Aqueous Alkaline Batteries

Advanced Science, EarlyView.
An N‐doped carbon‐confined Bi/Bi2O3 heterostructure enables ultrafast and reversible Bi0/Bi3+ phase conversion through heterointerface seeding. The pre‐established Bi/Bi2O3 interfaces provide nucleation‐active sites for heterophase regrowth, while the N‐C shell promotes electron transport and structural stability, overcoming kinetic limitations in ...
Jingwen Ma, Teng Wang, Jiaye Ye, Tong Yang, Zhongguo Zhao, Yuanyou Peng, Meimei Yu, Chaojiang Fan, Wenhu Li, Hongxia Wang   +9 more
wiley   +1 more source

Data for: 125I suppressed the Warburg effect via regulating miR-338/PFKL axis in hepatocellular carcinoma

, 2019
Data for: 125I suppressed the Warburg effect via regulating miR-338/PFKL axis in hepatocellular ...
Jiaping Zheng (7362740), Hui Zeng (142702), Jun Luo (120285), Guoliang Shao (4908157), Liwen Guo (1447288)   +4 more
core   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Warburg Family Collection. 1835-1855, 1934, 1975

This collection contains correspondence to members of the Warburg family primarily concerning business matters, though some social and political matters. The collection contains: a letter from S. Bleichröder to Madame E. Warburg extending well wishes
Warburg (Family)
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CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

I "Costumi teatrali" di Aby Warburg sotto la lente del musicologo

, 2021
Lo scritto prende in esame il testo di Aby Warburg sui Costumi teatrali per gli intermezzi fiorentini del 1589 dal punto di vista degli studi musicologici sulle origini del melodramma tra fine Cinque inizio Seicento, con particolare riferimento all ...
Badolato Nicola
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