Results 101 to 110 of about 53,264 (296)
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
The Warburg effect is genetically determined in inherited pheochromocytomas.
, 2009 The Warburg effect describes how cancer cells down-regulate their aerobic respiration and preferentially use glycolysis to generate energy. To evaluate the link between hypoxia and Warburg effect, we studied mitochondrial electron transport, angiogenesis
Julie Rivière +16 more
core +1 more source
International Journal of Trends in OncoScienceThe Warburg effect, defined by cancer cells’ preference for aerobic glycolysis over mitochondrial oxidative phosphorylation for energy production, has been a central topic in cancer research since its identification in 1924. This process involves elevated glucose uptake and lactate production, even in the presence of oxygen, supporting rapid cell ...
Dr. T. Shehnaz Begum +6 more
openaire +1 more source
Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation
Advanced Science, EarlyView.An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng +10 more
wiley +1 more source
Understanding the Warburg Effect
, 2012 This senior integrative exercise explores the current knowledge surrounding the genetic causes and metabolic effects of the Warburg effect in cancer ...
Amaefuna, Steve C.
core
Warburg effect hypothesis in autism Spectrum disorders
, 2018 Autism spectrum disorder (ASD) is a neurodevelopmental disease which is characterized by a deficit in social interactions and communication with repetitive and restrictive behavior. In altered cells, metabolic enzymes are modified by the dysregulation of
Jean-Noël Vallée, Alexandre Vallée
core +1 more source
Advanced Science, EarlyView.ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei +11 more
wiley +1 more source
Advanced Science, EarlyView.Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang +6 more
wiley +1 more source
Immunometabolism in Tuberculosis
Frontiers in Immunology, 2016 Immunometabolism, the study of the relationship between bioenergetic pathways and specific functions of immune cells, has recently gained increasing appreciation.
Lanbo eShi +2 more
doaj +1 more source
Machine‐Learning Microfluidic Minute‐Scale Microorganism Metrics Monitoring(M6)
Advanced Science, EarlyView.ABSTRACT On‐site monitoring of microorganisms remains challenging because of low concentrations, strong background interference, and dynamic aerosol diffusion, particularly for aerosol‐transmitted pathogens. Here, we report a rapid detection platform that integrates a Puri‐focusing microfluidic chip, electrochemical impedance spectroscopy (EIS), and ...
Ning Yang +14 more
wiley +1 more source