Results 91 to 100 of about 9,923,041 (290)

Host-Directed Therapy in Tuberculosis: Targeting Host Metabolism

Frontiers in Immunology, 2020
Mycobacterium tuberculosis (Mtb) has complex and intricate interactions with host immune cells. Mtb can survive, persist, and grow within macrophages and thereby circumvent detection by the innate immune system.
Jae-Sung Kim, Jae-Sung Kim, Ye-Ram Kim, Ye-Ram Kim, Chul-Su Yang, Chul-Su Yang   +5 more
doaj   +1 more source

The Reverse Warburg Effect.

, 2018
(A-C) Comparison of growth curves from axial simulations of tumor cells between the Warburg effect (WN = 2) and Reverse Warburg effect when 1, 3 and 5 layers of hijacked stromal cells are seeded between the source and tumor cells.
David Dai (457372), Arunodai Vudem (6061136), Abraham D. Stroock (2212393), Jeffrey D. Varner (197251), Mengrou Shan (6061133)   +4 more
core   +1 more source

Architecting Phase‐Selective Interlayers for Stable SiOx Lithium Storage via Dual‐Function Design

Advanced Science, EarlyView.
Silicon anodes offer high capacity but suffer severe volume expansion. Silicon monoxide (SiO) buffers expansion, yet uncontrolled lithiation irreversibly consumes lithium as Li2O and oxygen‐rich silicates. Here, we design a layered SiOx featuring a phase‐selective conductive interfacial interlayer (PSCII), i.e., a Li4SiO4‐rich, ion‐accessible ...
Zhenfei Chang, Wei Dong, Yingguang Zhang, Hangchen Qu, Yifei Wang, Xiaolong Zhao, Chu Wang, Ming Dong, Huizhi Wang, Jin Xuan, Yug Joshi, Dennis Y.C. Leung, Wending Pan   +12 more
wiley   +1 more source

Energy balance‐related factors in childhood and adolescence and risk of colorectal cancer expressing different levels of proteins involved in the Warburg‐effect

, 2022
Early‐life (childhood to adolescence) energy balance‐related factors (height, energy restriction, BMI) have been associated with adult colorectal cancer (CRC) risk. Warburg‐effect activation via PI3K/Akt‐signaling might explain this link. We investigated
Grabsch, H.I., Schouten, L.J.; id_orcid, Fazzi, G.E., Kim M. Smits, Fazzi, Gregorio E., Smits, K.M., Leo J. Schouten, Jenniskens, Josien C. A., Offermans, Kelly, Offermans, K., Colinda C. J. M. Simons, Smits, Kim M., Grabsch, Heike I., Kelly Offermans, Weijenberg, Matty P., van den Brandt, Piet A., Simons, C.C.J.M., Heike I. Grabsch, Matty P. Weijenberg, Iryna Samarska, Simons, Colinda C. J. M., van den Brandt, P.A., Schouten, Leo J., Gregorio E. Fazzi, Weijenberg, M.P., Piet A. van den Brandt, Samarska, Iryna, Samarska, I., Jenniskens, J.C.A., Josien C. A. Jenniskens   +29 more
core   +1 more source

Minimal Transport Units Govern Oxygen‐Defect Stabilization and Transport for Lightweight Solid Electrolytes

Advanced Science, EarlyView.
Lightweight borate chemistry combined with minimal transport units provides a new pathway for designing lightweight oxide‐ion solid electrolytes. ABSTRACT Solid electrolytes are central to electrochemical energy technologies, including fuel cells, sensors, catalysis, membrane separation, and electrolyser.
Xiaohui Li, Yongkang Zheng, Li Yang, Xiaoge Wang, Yuan Gou, Guanqun Cai, Jie Liu, Cheng Li, Kun Lin, Qiang Li, Mingxue Tang, Junliang Sun, Xianran Xing, Xiaojun Kuang   +13 more
wiley   +1 more source

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

Warburg non finito

, 2006
Introduzione agli appunti di viaggio di Aby Warburg in New ...
GHELARDI, Maurizio
core  

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

"Solemn, indefatigable and serious". Isadora Duncan and Martha Graham through the Warburg function. [PDF]

, 2023
openIl progetto di tesi magistrale sul quale si ha intenzione di lavorare prenderà in esame le categorie warburghiane e le userà come mezzo di analisi delle teorie coreutiche e delle partiture coreografiche di due coreografe del Novecento: Isadora ...
BACOCCOLI, MARTA
core  

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source