Results 241 to 250 of about 94,071 (310)

OpenPMX Software for Nonlinear Mixed‐Effect Models in Pharmacometrics: Precision Compared With NONMEM First‐Order Conditional Estimation

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 6, June 2026.
ABSTRACT Mixed effects models are a backbone of pharmacometrics, and NONMEM software, with the first‐order conditional method with interaction having become the de facto industry standard for model estimation. Documentation exists for the general mathematical methodology for estimation, but many technical and implementation details are lacking. OpenPMX
Douglas J. Eleveld, Jeroen V. Koomen, Jasper Stevens, Pieter J. Colin, Michel M. R. F. Struys   +4 more
wiley   +1 more source

Pyoderma Gangrenosum-Like Ulcer Secondary to Antiphospholipid Syndrome.

Indian J Dermatol
Mijovic F, Brent G, Sampson SA, Paget SNJ.   +3 more
europepmc   +1 more source

Benzofuran‐Based Uricosuric Agents: History, Roles, and Challenges

ChemistrySelect, Volume 11, Issue 24, 25 June 2026.
Benzofuran‐based uricosuric agents represent a privileged medicinal chemistry scaffold for gout therapy. Structural optimization of benzbromarone‐related derivatives has improved hURAT1 inhibitory potency, metabolic stability, and urate‐lowering efficacy, while reducing hepatotoxic liability.
Raed M. Al‐Zoubi, Basma Hanbali, Mai Elaarag, Zainab Fares, Enas A. Al‐Hurani, Sally R. Al‐Zoubi, Mohanad Shkoor, Abdelali Agouni   +7 more
wiley   +1 more source

Leveraging Machine Learning to Predict Warfarin Sensitivity in the Puerto Rican Population: A Pharmacogenomic Approach. [PDF]

Int J Environ Res Public Health
Martínez-Jiménez JE, Ortega-Lampón Y, Cedres-Rivera D, Heredia-Negrón F, Roche-Lima A, Duconge J.   +5 more
europepmc   +1 more source

Subgroup Identification via Multiple Change Point Detection: Methods and Applications

WIREs Computational Statistics, Volume 18, Issue 2, June 2026.
Subgroup identification methods facilitate the discovery of clinically meaningful subpopulations with differing disease progression, improving personalized risk assessment and treatment strategies. ABSTRACT Subgroup identification is a significant research area in statistics and machine learning, aiming to partition a heterogeneous population into more
Yaguang Li, Jingli Wang, Da Zhao, Jialiang Li   +3 more
wiley   +1 more source

A study to evaluate the impact of PB-119 injection (a pegylated exenatide formulation) on the pharmacokinetic profiles of Digoxin and Warfarin sodium in healthy subjects. [PDF]

SAGE Open Med
Yu Y, Hu W, Zhang T, Peng Y, Ding J, Wang X, He H, Zhou D, Han D, Cao J, Cheng N, Zhou J, Zhou H.   +12 more
europepmc   +1 more source

Warfarin-Durian interaction: A case study bridging clinical outcomes and metabolic profiling through metabolomics. [PDF]

Toxicol Rep
Hiranchatchawal N, Wannaphueak K, Rattanasuwan P, Lertpongpipat P, Konguthaithip G, Jaikang C, Tajai P.   +6 more
europepmc   +1 more source

Warfarin-associated Chronic Subdural Hematomas May Exhibit a Shorter Post-traumatic Interval: An Observational Study. [PDF]

Neurol Med Chir (Tokyo)
Köksal V, Engin R, Demirel C, Abanoz E, Türköz D, Çakir T.   +5 more
europepmc   +1 more source

Acetylsalicylic acid use for artial fibrillation and bleeding risk. [PDF]

Can Fam Physician
Braschi É, Young J.
europepmc   +1 more source

Anticoagulant adherence and associated complications and readmissions in older valve surgery adults: insights from a retrospective cohort study. [PDF]

BMC Geriatr
Roan JN, Hu YS, Chuang TJ, Wu YL, Yang YC, Ku HC.   +5 more
europepmc   +1 more source