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Pharmaceutics, 2022 Warfarin is extensively used for venous thromboembolism and other coagulopathies. In clinical settings, warfarin is administered as a mixture of S- and R-warfarin, and both enantiomers are metabolized by multiple cytochrome P450 enzymes into many ...
Shasha Jin +6 more
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INTERACTIONS OF WARFARIN [PDF]
Biomedical Papers, 2001 In this article, the author reviews and updates the basis of interactions with warfarin, illustrated with appropriate examples. The interactions with drugs, medicinal herbs and foods are summarised.
openaire +3 more sources
Rivaroxaban vs warfarin in high-risk patients with antiphospholipid syndrome.
Blood, 2018 Rivaroxaban is an effective and safe alternative to warfarin in patients with atrial fibrillation and venous thromboembolism. We tested the efficacy and safety of rivaroxaban compared with warfarin in high-risk patients with thrombotic antiphospholipid ...
V. Pengo +21 more
semanticscholar +1 more source
Warfarin pharmacogenetics [PDF]
Trends in Cardiovascular Medicine, 2015 The cytochrome P450 (CYP) 2C9 and vitamin K epoxide reductase complex 1 (VKORC1) genotypes have been strongly and consistently associated with warfarin dose requirements, and dosing algorithms incorporating genetic and clinical information have been shown to be predictive of stable warfarin dose.
Julie A, Johnson, Larisa H, Cavallari
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JAMA Network Open, 2020 Key Points Question What is the role of warfarin in preventing ischemic strokes in patients with atrial fibrillation and end-stage renal disease? Findings This meta-analysis found that, although the current literature is only observational, warfarin use ...
M. Randhawa +6 more
semanticscholar +1 more source
Thrombosis Journal, 2008 Introduction Atrial fibrillation affects an estimated 2.5 million Americans and incurs an average annual stroke risk of 4.5% per year. Despite warfarin reducing stroke risk by approximately 66%, prior studies show warfarin usage rates to be about 50 ...
Cavalcante Joao +5 more
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High clearance of (S)‐warfarin in a warfarin‐resistant subject. [PDF]
British Journal of Clinical Pharmacology, 1993 A 30 year old black male required a 60 mg daily dose of warfarin to elicit a therapeutic anticoagulant response (normal warfarin dose 2.5‐ 10 mg day‐1; maximum 15 mg day‐1). Hereditary warfarin resistance was suspected after compliance, diet, concurrent medication and any gastrointestinal disorder were eliminated as contributory causes. The disposition
AA Trowbridge +6 more
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Scientific Reports, 2017 Recent global deregulation of ginseng as the table food raises our concern about the possible ginseng-warfarin interaction that could be life-threatening to patients who take warfarin for preventing fatal strokes and thromboembolism while using ginseng ...
Haiyan Dong +8 more
doaj +1 more source
Warfarin Pharmacogenetics [PDF]
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2008 Significant interest in the pharmacogenetics of warfarin therapy has been triggered with the recent package insert update that highlights the potential role of pharmacogenetics in improving the safety and effectiveness of warfarin. We review the evidence of the influence of the two key genes of interest, the cytochrome P450 2C9 gene, CYP2C9, and the ...
Nita A, Limdi, David L, Veenstra
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JAMA Neurology, 2019 Key Points Question Is dabigatran etexilate or dose-adjusted warfarin efficacious and safe to use in preventing the recurrence of venous thrombotic events among patients with cerebral venous thrombosis? Findings In this exploratory randomized, open-label
J. Ferro +14 more
semanticscholar +1 more source