Results 11 to 20 of about 102,210 (307)

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin. [PDF]

Clin Pharmacol Ther
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Shaul C, Mujahed W, Idries I, Wanounou M, Bialer M, Caraco Y.   +5 more
europepmc   +2 more sources

4-Ethyl phenyl sulfate binding to human serum albumin. [PDF]

Protein Sci
Abstract Protein‐bound uremic toxins (PBUTs) such as 4‐ethylphenyl sulfate (4‐EPS) challenge kidney failure management due to strong binding to human serum albumin (HSA), thus limiting dialysis clearance. This study examined 4‐EPS–HSA interactions using saturation transfer difference nuclear magnetic resonance spectroscopy (STD‐NMR), isothermal ...
Niestanak VD, Zattoni J, McKay RT, Tonelli M, Aminpour M, Unsworth LD.   +5 more
europepmc   +2 more sources

Warfarin anticoagulation exacerbates the risk of hemorrhagic transformation after rt-PA treatment in experimental stroke: therapeutic potential of PCC [PDF]

, 2011
Background: Oral anticoagulant therapy (OAT) with warfarin is the standard of stroke prevention in patients with atrial fibrillation. Approximately 30% of patients with cardioembolic strokes are on OAT at the time of symptom onset.
Förch, Christian, Waltraud Pfeilschifter, Daniel Spitzer, Pfeilschifter, Josef (Prof. Dr.), Helmuth Steinmetz, Spitzer, Daniel, Steinmetz, Helmuth, Steinmetz Helmuth, Christian Foerch, Pfeilschifter, Waltraud, Josef Pfeilschifter, Pfeilschifter Waltraud, Spitzer Daniel, Foerch Christian, Pfeilschifter Josef   +14 more
core   +2 more sources

Epistaxis in Patients Receiving Oral Anticoagulants and Antiplatelet: Prevalence, Risk Factors at a Tertiary Care Hospital in Nepal: A Cross-Sectional Study. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Epistaxis is a common complication associated with oral anticoagulant and antiplatelet therapies, often leading to significant morbidity. In recent years, the incidence of cardiovascular disease in Nepal has risen dramatically, driving a widespread use of these medications and heightened concerns regarding bleeding ...
Sah SK, Gupta AK, Acharya S, Thakur SK, Chaudhary R, Pandeya S, Budthapa A, K C V, Khadgi S, Bajracharya M.   +9 more
europepmc   +2 more sources

Standardized warfarin monitoring decreases adverse drug reactions

BMC Family Practice, 2019
Background While warfarin is the most commonly prescribed medication to prevent thromboembolic disorders, the risk of adverse drug reactions (ADR) poses a serious concern.
Lisa B. E. Shields, Paula Fowler, Diane M. Siemens, Douglas J. Lorenz, Kenneth C. Wilson, Steven T. Hester, Joshua T. Honaker   +6 more
doaj   +1 more source

Edoxaban: an update on the new oral direct factor Xa inhibitor. [PDF]

, 2014
Edoxaban is a once-daily oral anticoagulant that rapidly and selectively inhibits factor Xa in a concentration-dependent manner. This review describes the extensive clinical development program of edoxaban, including phase III studies in patients with ...
Camm, AJ, Bounameaux, H, A. John Camm, Henri Bounameaux   +3 more
core   +1 more source

Enzyme polymorphism in warfarin dose management after pediatric cardiac surgery

Research in Cardiovascular Medicine, 2015
Background: Warfarin is an anticoagulant and is widely used for the prevention of thromboembolic events. Genetic variants of the enzymes that metabolize warfarin, i.e.
Avisa Tabib, Babak Najibi, Mohammad Dalili, Ramin Baghaei, Behzad Poopak   +4 more
doaj   +1 more source

Initiation of warfarin is associated with decreased mortality in patients with infective endocarditis: A population-based cohort study. [PDF]

, 2023
The use of warfarin to prevent thromboembolism in patients with infective endocarditis (IE) remains controversial due to potentially increased bleeding risks. Population-based retrospective cohort study. Patients aged 18 or older and diagnosed with IE in
Tse, Gary, Chan, Sunny Ching Long, Chou, Oscar Hou In, Cheung, Bernard Man Yung, Wong, Wing Tak, Wai, Abraham Ka-Chung, Liu, Tong, Chang, Carlin, Lee, Teddy Tai Loy, Lee, Sharen, Chan, Jeffrey Shi Kai, Lip, Gregory Y H   +11 more
core   +1 more source

An Atypical Case of Warfarin-Induced Skin Necrosis

Clinical Practice and Cases in Emergency Medicine, 2017
Skin necrosis is a relatively rare, potentially fatal side effect of warfarin. It is most commonly reported within 10 days of initiation of therapy in warfarin-naïve patients.
Lindsay R. Sklar, Anne Messman
doaj   +1 more source

Fasting and warfarin

Journal of Fasting and Health, 2014
Recently, we reported the findings of a study on the effects of Ramadan fasting on a group of 32 Muslim patients taking warfarin.13 Weekly INR (international normalized ratio) readings were taken from subjects with previously stable INRs over a three-month period spanning pre-Ramadan to post-Ramadan. We found a statistically significant increase in the
Lai, YF, Ng, HJ
openaire   +3 more sources