Results 21 to 30 of about 2,357,394 (215)

Management of heparin resistance due to antithrombin deficiency in a Chinese pregnant woman: a case report

Journal of International Medical Research, 2021
Untreated individuals with antithrombin (AT) deficiency are at higher risk of thrombosis and adverse pregnancy outcomes. The present recommendations are mostly empirical for treating patients with AT deficiency during pregnancy because of the absence of ...
Xiaoxin Zhang, Feng Guo, Qiaohong Wang, Wenxin Bai, Aimin Zhao   +4 more
doaj   +1 more source

The VKORC1 ER-luminal loop mutation (Leu76Pro) leads to a significant resistance to warfarin in black rats (Rattus rattus) [PDF]

, 2021
Well-known 4-hydroxycoumarin derivatives, such as warfarin, act as inhibitors of the vitamin K epoxide reductase (VKOR) and are used as anticoagulants. Mutations of the VKOR enzyme can lead to resistance to those compounds.
Igarashi, Manabu, Ikenaka, Yoshinori, Ishizuka, Mayumi, Tanaka, Kazuyuki D., Triki, Dhoha, Li, Xinhao, Nakayama, Shouta M. M., Fourches, Denis, Takeda, Kazuki, Tanikawa, Tsutomu, Dhoha Triki, Kazuki Takeda, Denis Fourches, Manabu Igarashi, Shouta M.M. Nakayama, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Xinhao Li, Yoshinori Ikenaka, Mayumi Ishizuka   +19 more
core   +1 more source

The genetic mechanisms of warfarin resistance in Rattus rattus found in the wild in Japan [PDF]

, 2012
Warfarin is commonly used worldwide as a rodenticide. It inhibits blood coagulation by inhibiting vitamin K 2,3-epoxide reductase (VKOR) activity leading to hemorrhage.
Harunari, Tsunehito, Ando, Shima, Ikenaka, Yoshinori, Ishizuka, Mayumi, Tanaka, Kazuyuki D., Min, Hee Won, Okajima, Fumie, Fujita, Shoichi, Tanikawa, Tsutomu, Kawai, Yusuke K.   +9 more
core   +1 more source

Large-scale structure of brown rat (Rattus norvegicus) populations in England: effects on rodenticide resistance [PDF]

, 2015
The brown rat (Rattus norvegicus) is a relatively recent (
Eleanor P. Jones, Mohd Z.H. Haniza, R. H. Smith (7659080), Jones, Eleanor P., Adams, Sally, Sally Adams, MacNicoll, Alan, Mark S. Lambert, Eamonn B. Mallon, S. Adams (1469704), Mallon, Eamonn B., M. S. Lambert (7659083), Haniza, Mohd Z.H., Alan MacNicoll, Eamonn Bernard Mallon (7607027), Smith, Robert H., Robert H. Smith, E. P. Jones (7659074), M. Z. Haniza (7659071), A. M. MacNicoll (7659077), Lambert, Mark S.   +20 more
core   +2 more sources

Culture-Negative Infective Endocarditis Presumed due to Brucella Causing Rapid Native Aortic Valve Destruction in a Young Adult: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Culture‐negative endocarditis with features consistent with Brucella can rapidly destroy a normal aortic valve in young adults. 2023 Duke‐ISCVID criteria (clinical/imaging findings plus histopathology), supported by serology and occupational exposure enabled urgent combined antimicrobial‐surgical management without culture confirmation ...
Nassar B, Gharo KI, Ramahi O, Ghannam H, Romana A, Hashhash KA.   +5 more
europepmc   +2 more sources

Genetic Regulation of Warfarin Metabolism and Response

, 2003
Genetic factors make an important contribution to the wide interindividual variation in warfarin dose requirement. Several cytochromes P450, each of which shows genetic polymorphism leading to interindividual variation in levels of activity, contribute ...
Daly AK, Aithal GP
core   +4 more sources

Novel revelation of warfarin resistant mechanism in roof rats (Rattus rattus) using pharmacokinetic/pharmacodynamic analysis [PDF]

, 2016
Roof rats (Rattus rattus) live mainly in human habitats. Heavy use of rodenticides, such as warfarin, has led to the development of drug resistance, making pest control difficult.
Ikenaka, Yoshinori, Ishizuka, Mayumi, Tanaka, Kazuyuki D., Nakayama, Shouta M. M., Mizukawa, Hazuki, Takeda, Kazuki, Tanikawa, Tsutomu, Nakayama, Shouta M.M.   +7 more
core   +2 more sources

Lemierre Syndrome in a Patient With Splenectomy Secondary to Pyruvate Kinase Deficiency, Complicated by Heparin Resistance

Journal of Investigative Medicine High Impact Case Reports, 2021
Lemierre syndrome was first documented in the literature in 1936, and is defined as septic thrombophlebitis of the internal jugular vein. It is typically a result of oropharyngeal infection causing local soft tissue inflammation, which spreads to ...
Kiley Clark BS, Morgan Sly BA, Pearl Chan BA, Hobart Lai DO, Hadi Ali MD, David Contreras MD, Ramanjeet Sidhu MD, Janpreet Bhandohal MD, Sikha Mishra MD, Rasha Kuran MD, Rahul Dev Polineni MD   +10 more
doaj   +1 more source

Biochemistry of resistance to warfarin in a French strain of the Norway rat (Rattus norvegicus)

, 2005
International audienceWarfarin-susceptible and warfarin-resistant Norway rat (Rattus norvegicus) strains from France were studied to determine the mechanism of resistance to warfarin.
Longin-Sauvageon, Christiane, Lasseur, R., Benoit, Etienne, Berny, Philippe   +3 more
core   +2 more sources

Interactional resistance between patients with atrial fibrillation and cardiologists in consultation on treatment with warfarin : the value of shared decision-making [PDF]

, 2012
Rationale: Atrial fibrillation (AF) increases the risk of stroke and it can be reduced by treatment with warfarin. Some patients consider that warfarin is a stressful treatment with undesired effects and the perceived barriers include unwillingness to ...
Siouta, Eleni,, Hedman, Karl,, Hedberg, Berith,, Broström, Anders,   +3 more
core   +6 more sources