Results 81 to 90 of about 2,357,394 (215)

Development of a population pharmacokinetic model using combined paediatric and adult data for four pulmonary arterial hypertension drugs

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3611-3621, October 2026.
Aims Pulmonary arterial hypertension (PAH) is a syndrome characterized by elevated pulmonary artery pressure. We developed a population pharmacokinetic (PPK) model using combined plasma drug concentration data from Japanese paediatric (<15 years) and adult (≥15 years) patients with PAH to investigate the pharmacokinetic characteristics of PAH ...
Motoyasu Miura, Shimako Tanaka, Ririka Aihara, Shun Yamamoto, Yasumi Nakashima, Yasuharu Kashiwagura, Akio Hakamata, Sachiko Miyakawa, Mariko Tatsuguchi, Keiichi Odagiri, Noriyuki Namiki, Naoki Inui, Hiroshi Watanabe, Shinya Uchida   +13 more
wiley   +1 more source

Anticoagulation Therapies and microRNAs in Heart Failure

Biomolecules
Heart Failure (HF) remains a major cause of mortality despite the advances in pharmacological treatment. Anticoagulation therapies, including Clopidogrel, Aspirin, Warfarin, and novel oral anticoagulants (NOACs) such as Apixaban, Rivaroxaban, Edoxaban ...
Lucia Spartano, Maria Lombardi, Chiara Foglieni   +2 more
doaj   +1 more source

Developmental Toxicity Study for the Antimalarial Drug Combination Cabamiquine‐Pyronaridine Using a Translational Approach

Birth Defects Research, Volume 118, Issue 10, October 2026.
ABSTRACT Background The safety of pharmacological treatments during pregnancy is a significant concern, as many medications lack comprehensive reproductive safety data. This creates gaps in therapeutic options for pregnant women, particularly malaria, which poses serious risks to maternal and fetal health.
Wookyung Kim, Geum‐Sil Cho, Andreas Gado, Tobias Hyun Ho Baeurle, Habib Karimi, Filippo Venezia, Claude Oeuvray, Thomas Spangenberg, Sebastian G. Wicha, Claudia Demarta‐Gatsi   +9 more
wiley   +1 more source

Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase

, 2018
Key PointsAnalysis of full VKORC1 reduction of vitamin K epoxide vs the individual reactions shows that warfarin uncouples the 2 reactions. A mutant becomes more active than wild-type VKORC1 only in the presence of warfarin, revealing a novel mechanism ...
Kathleen L. Berkner, Kevin W. Hallgren, Lee Wilson, Mark A. Rishavy, Savita Singh, Kurt W. Runge   +5 more
core   +1 more source

Emergency cardiac surgery and heparin resistance in a patient with essential thrombocythemia

JA Clinical Reports, 2016
A 66-year-old man with thrombocytosis was brought to our hospital to undergo removal of a left ventricular thrombus. He had developed cerebral infarction 6 days before presenting to the hospital and suffered from right incomplete hemiparalysis.
Mika Nakanishi, Eri Oota, Takehiro Soeda, Kaoru Masumo, Yukihiko Tomita, Takeshi Kato, Toshihiro Imanishi   +6 more
doaj   +1 more source

A Case of Unexplained Warfarin Resistance: A Case Report and Literature Review. [PDF]

J Tehran Heart Cent, 2023
Favaedi M, Pasebani Y, Kabiri A, Rafati A, Jalali S, Kiani A, Ahmadi R, Shadmehr A, Amirmazloomi A, Khajali Z.   +9 more
europepmc   +1 more source

Next‐Generation Sequencing‐Based Molecular Profiling and Management of Advanced Solid Tumors: A Real‐World Experience in a Community‐Based Academic Cancer Center

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Advances in molecular and cell biology have led to a paradigm shift in cancer management. We implemented next‐generation sequencing (NGS) at our community‐based academic cancer center over a decade ago. We sought to optimize the use of genomics and understand its impact in identifying actionable genomic alterations to determine ...
Gayathri Moorthy, Annette Sereika, Karen Kaul, Megan Parilla, Mir B. Alikhan, Michael Bouma, Dyson Wake, Peter J. Hulick, Henry M. Dunnenberger, Linda M. Sabatini, Mathew Yang, Kathy A. Mangold, Erin Proctor, Nicholas Evans, Nicholas Miller, Donald L. Helseth Jr, Darryck Maurer, Justin Brueck, Janardan Khandekar, Bruce Brockstein   +19 more
wiley   +1 more source

Warfarin resistance in Rattus losea in Guangdong

, 2008
Control of rodent populations is performed worldwide with coumarin derivatives, such as warfarin. After widespread use, their effect has been diminished by the rapid spread of resistant rodents.
Ming Li, Jiayin Dai, Dandan Yao, Zhiyong Feng, Wenqin Zhong, Jianshe Wang, Jingjing Sui   +6 more
core  

Peumus boldus: Revealing the Pharmaceutical Potential of the Chilean Forest

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
P. boldus emerge as a promising yet underexplored source of bioactive compounds. Current evidence highlights antioxidant, anti‐inflammatory, antimicrobial, and cytoprotective activities associated with their unique phytochemical profile. This review integrates chemical composition, biological properties, proposed molecular mechanisms, and safety ...
Marta Rodríguez‐Ceballos, Valentina Jara, Sofía Díaz‐Cornejo, Valentina Morales, Rómulo Santelices‐Moya, Miguel Aguilera, Cristian Atala, María Carolina Otero, Felipe Gordillo‐Fuenzalida   +8 more
wiley   +1 more source

High-Flow Nasal Cannula Therapy in a Patient with Reperfusion Pulmonary Edema following Percutaneous Transluminal Pulmonary Angioplasty

Case Reports in Pulmonology, 2014
A 62-year-old woman with Wolff-Parkinson-White syndrome was with recent worsening of dyspnea to New York Heart Association functional status Class III. The patient was diagnosed as having central type chronic thromboembolic pulmonary hypertension.
Kiyoshi Moriyama, Toru Satoh, Akira Motoyasu, Tomoki Kohyama, Mariko Kotani, Riichiro Kanai, Tadao Ando, Tomoko Yorozu   +7 more
doaj   +1 more source