Results 81 to 90 of about 993,218 (302)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Numerical calculations of two dimensional, unsteady transonic flows with circulation [PDF]

The feasibility of obtaining two-dimensional, unsteady transonic aerodynamic data by numerically integrating the Euler equations is investigated. An explicit, third-order-accurate, noncentered, finite-difference scheme is used to compute unsteady flows ...
Beam, R. M., Warming, R. F.
core   +1 more source

Northwestern Pacific typhoon intensity controlled by changes in ocean temperatures. [PDF]

, 2015
Dominant climatic factors controlling the lifetime peak intensity of typhoons are determined from six decades of Pacific typhoon data. We find that upper ocean temperatures in the low-latitude northwestern Pacific (LLNWP) and sea surface temperatures in ...
McWilliams, James C, Mei, Wei, Pasquero, Claudia, Primeau, François, Xie, Shang-Ping   +4 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Stability of semidiscrete approximations for hyperbolic initial-boundary-value problems: Stationary modes [PDF]

Spatially discrete difference approximations for hyperbolic initial-boundary-value problems (IBVPs) require numerical boundary conditions in addition to the analytical boundary conditions specified for the differential equations.
Beam, Richard M., Warming, Robert F.
core   +1 more source

Seasonal dynamics of soil respiration and nitrogen mineralization in chronically warmed and fertilized soils [PDF]

, 2011
Although numerous studies have examined the individual effects of increased temperatures and N deposition on soil biogeochemical cycling, few have considered how these disturbances interact to impact soil C and N dynamics.
Contosta, Alexandra R., Cooper, Andrew B., Frey, Serita D.   +2 more
core   +2 more sources

Warming up brane-antibrane inflation

, 2011
We show that, in constructions with additional intersecting D-branes, brane-antibrane inflation may naturally occur in a warm regime, such that strong dissipative effects damp the inflaton's motion, greatly alleviating the associated eta-problem.
Arjun Berera, C. Johnson, João G. Rosa, Mar Bastero-Gil, N. Barnaby, S. Shandera   +5 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Effect of Warming on Soil Fungal Community Along Altitude Gradients in a Subalpine Meadow

Microorganisms
The subalpine grassland ecosystem is sensitive to climatic changes. Previous studies investigated the effects of warming on grassland ecosystems at a single altitude, with little information about the response of subalpine meadows to warming along ...
Jing Yin, Dandan Yuan, Jing Lu, He Li, Shuzheng Luo, Jianhua Zhang, Xingjia Xiang   +6 more
doaj   +1 more source