Results 101 to 110 of about 481,746 (305)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Saving the Planet and Creating Jobs: W3 Atlantic Forum 2011 - Poster (English)
, 2011 Poster from a two-day conference held at St Thomas University on September 29-30 2011.Work in a Warming World ...
Work in a Warming World (W3)
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Long term trend of chemical oxygen demand in Saroma-ko Lagoon, Japan; possible effects of climatic warming [PDF]
, 2008 A trend of shortening duration of ice coverage has been reported in many rivers, ponds and lakes around the world due to climatic warming. The shortening will have much influence on organic production due to the greater supply of light intensity and ...
Akihiro Shiomoto
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Young Green Workers Charter [PDF]
, 2012 The students who participated in the W3’s first Climate Change, Youth and Jobs Institute, from February 2012, have developed a working charter that identifies the steps necessary for achieving greener workplaces.Work in a Warming World ...
Work in a Warming World (W3)
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Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Is New Zealand globally warming?
, 2011 NIWA proposes a seven-station temperature series to assess a globally warming trend. The warming trend predicted by NIWA is a result of their arbitrary corrections of measured temperatures to account for change of site.
Boretti, Alberto +3 more
core +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Work in a Warming World 2013 Workshop
, 2013 Conference papers from the annual Researchers Workshop, January 25 & 26 2013 held at the University of Toronto, Victoria College.Work in a Warming World ...
Shields, John +20 more
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Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source