Results 71 to 80 of about 8,838,195 (361)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Groundwater markets and water use efficiency: The case of Karnataka [PDF]
Research highlight based on a paper titled “Groundwater markets promoting efficiency in water use in agriculture in Karnataka.”Water market, Groundwater extraction, Water use efficiency, Wells, Crop production, Irrigation water, Domestic water, Pricing ...
Chandrakanth, Mysore G. +2 more
core +4 more sources
Reduced stomatal density in bread wheat leads to increased water-use efficiency
Journal of Experimental Botany, 2019 Crops that require less water but produce the same yield would aid agriculture. We show that engineering lower stomatal density in wheat leaves can improve water-use efficiency, yet maintain yield.
Jessica A. Dunn +8 more
semanticscholar +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Technical efficiency of water use and its determinants, study at smallscale irrigation schemes in North-West Province, South Africa [PDF]
, 2007 This paper analyses the efficiency with which water is used in small-scale irrigation schemes in North-West Province in South Africa and studies its determinants.
Buysse, Jeroen +3 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Speedy stomata, photosynthesis and plant water use efficiency.
New Phytologist, 2018 Contents Summary 93 I. Introduction 93 II. Influence of the speed of gs responses on A and Wi 93 III. Determinants of the rapidity of gs responses 95 IV.
T. Lawson, S. Vialet-Chabrand
semanticscholar +1 more source
Global patterns, trends, and drivers of water use efficiency from 2000 to 2013 [PDF]
, 2015 Water use efficiency (WUE; gross primary production [GPP]/evapotranspiration [ET]) estimates the tradeoff between carbon gain and water loss during photosynthesis and is an important link of the carbon and water cycles.
Guo, Qinghua +5 more
core +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source