Results 81 to 90 of about 8,838,195 (361)
Water, 2018 The demand for fresh water is on the increase, and the irrigation industry in Australia is looking to a future with less water. Irrigation consumes the bulk of the water extracted from various sources, and hence the efficiency of its use is of outmost ...
R. Koech, P. K. Langat
semanticscholar +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Water use of wheat, corn and sunflower in the semiarid pampas [PDF]
Ciencia del Suelo, 2017 Crop water use in semiarid environments allows designing management strategies to improve water use efficiency. Our objective was to estimate wheat (Triticum aestivum L.), maize (Zea mays L.) and sunflower (Helianthus annuus L.) water use in the Semiarid
Alfredo A Bono +2 more
doaj
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Increased carbon uptake and water use efficiency in global semi-arid ecosystems
Environmental Research Letters, 2020 The semi-arid ecosystems dominate the inter-annual variability of the global carbon sink and the driving role of semi-arid ecosystems is becoming increasingly important. However, the impacts of climate change on the dynamics of carbon and water fluxes in
Li Zhang +4 more
semanticscholar +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Biofuel, land and water: maize, switchgrass or Miscanthus?
Environmental Research Letters, 2013 The productive cellulosic crops switchgrass and Miscanthus are considered as viable biofuel sources. To meet the 2022 national biofuel target mandate, actions must be taken, e.g., maize cultivation must be intensified and expanded, and other biofuel ...
Qianlai Zhuang, Zhangcai Qin, Min Chen
doaj +1 more source
Soil & Environment, 2020 The availability of limited irrigation water in rainfed regions is the most challenging constraint to harvest the maximum agronomic benefits. The adaptation of smart water-saving techniques is desperate to combat soil moisture stress and soil quality ...
Aftab Ahmad Shaikh +9 more
doaj +1 more source