Results 71 to 80 of about 11,083,935 (337)

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

The Ecological Role of Water-Column Microbes in the Sea*

open access: yes, 1983
Recently developed techniques for estimating bacterial biomass and productivity indicate that bacterial biomass in the sea is related to phytoplankton concentration and that bacteria utilise 10 to 50 % of carbon fixed by photosynthesis.
F. Azam   +5 more
semanticscholar   +1 more source

Water water!

open access: yes, 2018
Coverage ...
openaire   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Water molecules on the liquid superlubricity interfaces achieved by phosphoric acid solution

open access: yesBiosurface and Biotribology, 2018
The superlubricity mechanism of phospholipid molecules on biological surfaces and interfaces has been receiving much attention. Since the superlubricity can be achieved with a phosphoric acid aqueous solution, the interaction of the phosphate group with ...
Yuan Gao   +4 more
doaj   +1 more source

Water stress and water wars

open access: yesThe Economics of Peace and Security Journal, 2007
This essay argues three propositions: (1) by 2025 roughly one third of the world's population will be living in countries which are water-stressed, at least by conventional criteria; (2) nevertheless, macro evidence does not portend that the world will be unable to feed its growing population at that time; (3) interstate armed conflicts over water ...
openaire   +4 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

Measurement of Heavy Metal Pollution in Water and Estimation of Potential Metal Hazards on the Life of Anzali wetland in 2017

open access: yesMuhandisī-i Bihdāsht-i Muḥīṭ, 2021
Anzali Wetland is one of the most important international wetlands located on the southern shore of the Caspian Sea. This wetland is habitat to valuable fish, aquatic animals and birds that are of ecological and economic importance.
Masoumeh Khosravi   +2 more
doaj  

Home - About - Disclaimer - Privacy