Results 51 to 60 of about 2,686,055 (278)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

PEMANFAATAN MATA AIR DUKUH BLAHKIUH UNTUK SISTEM PELAYANAN AIR TERINTEGRASI

Jurnal Sumber Daya Air
Spring water is one of the natural resources that are beneficial to human life such as fulfilling the needs of clean water, irrigation, and others. Non-integrated spring management has the potential to create conflicts among water users, as is the case ...
I Gusti Ngurah Kade Mahesa Adi Wardana, Ketut Wiwin Andayani, I Nyoman Anom Purwa Winaya   +2 more
doaj   +1 more source

Peranan Sumber Daya Air terhadap Pemanfaatan Ruang Berdasarkan Keseimbangan Tata Air di Wilayah Sub DAS Gajah Wong

Jurnal Pembangunan Wilayah dan Kota, 2014
This reserach is aimed to analyse the condition of water system balance and its role towards the area utilization in Gajah Wong sub catchment region. The method used in this research is by using the analysis of water balance by applying the comparison of
Nowo Indriyatno
doaj   +1 more source

The application of methods of ecosystem analysis to the evaluation of water quality [PDF]

, 1980
Guided by experience and the theoretical development of hydrobiology, it can be considered that the main aim of water quality control should be the establishment of the rates of the self-purification process of water bodies which are capable of ...
Kozhova, O.M.
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Study on dynamic response of saturated soil around piles under vertical vibration

Yantu gongcheng xuebao
A coupled pile-saturated soil model is proposed to investigate the response of saturated soil under three-dimensional axisymmetric conditions based on Biot's theory of saturated porous media.
FU Pengcheng1, 2 , WU Juntao1, 2 , YI Enze1, 2, WANG Kuihua1, 2, ZHANG Zhiqing3, TANG Lüjun4
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

PEMETAAN NERACA SUMBERDAYA AIR KABUPATEN SABU RAIJUA, NUSA TENGGARA TIMUR, INDONESIA

Geoplanning: Journal of Geomatics and Planning, 2015
The balance of water resources reflects changing water resource potential within a certain time. Sabu Raijua Regency is a regency in East Nusa Tenggara Province that has physical problems in the water supply.
Roswidyatmoko Dwihatmojo, Dwi Maryanto
doaj   +1 more source

Water reuse for irrigated agriculture in Jordan: challenges of soil sustainability and the role of management strategies [PDF]

, 2010
Reclaimed water provides an important contribution to the water balance in water-scarce Jordan, but the quality of this water presents both benefits and challenges. Careful management of reclaimed water is required to maximize the nutrient benefits while
Carr G., Darmame K., Kitchin R., Lazarova V., Maas E. V., Ministry of Water Jordan Irrigation., Oster J. D., Rowell D. L.   +7 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source