Results 41 to 50 of about 225,214 (264)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
UPStream: Automated hydraulic design of pressurized water distribution networks
SoftwareX, 2017 Hydraulic design of pressurized water distribution networks constitutes a time consuming process in engineering applications, requiring proper selection of pipe diameters so certain regulatory constrains are met.
Stergios Emmanouil, Andreas Langousis
doaj +1 more source
Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2023 This paper proposes the optimization model using Artificial Immune Systems, depending on a model calibration, in order to determine worn out pipes with low Hazen-Williams roughness coefficient causing pressure loss in the water distribution networks. The
Mirac Eryiğit
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Contamination Source Inference in Water Distribution Networks
Revista Cubana de Física, 2017 We study the inference of the origin and the pattern of contamination in water distribution networks after the observation of contaminants in few nodes of the network.
A. Lage-Castellanos, E. Ortega
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Graph Neural Networks for Pressure Estimation in Water Distribution Systems
Water Resources ResearchPressure and flow estimation in water distribution networks (WDNs) allows water management companies to optimize their control operations. For many years, mathematical simulation tools have been the most common approach to reconstructing an estimate of ...
Huy Truong +3 more
doaj +1 more source