Results 41 to 50 of about 11,715,296 (244)
UPStream: Automated hydraulic design of pressurized water distribution networks
SoftwareX, 2017 Hydraulic design of pressurized water distribution networks constitutes a time consuming process in engineering applications, requiring proper selection of pipe diameters so certain regulatory constrains are met.
Stergios Emmanouil, Andreas Langousis
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Contamination Source Inference in Water Distribution Networks
Revista Cubana de Física, 2017 We study the inference of the origin and the pattern of contamination in water distribution networks after the observation of contaminants in few nodes of the network.
A. Lage-Castellanos, E. Ortega
doaj
Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2023 This paper proposes the optimization model using Artificial Immune Systems, depending on a model calibration, in order to determine worn out pipes with low Hazen-Williams roughness coefficient causing pressure loss in the water distribution networks. The
Mirac Eryiğit
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Graph Neural Networks for Pressure Estimation in Water Distribution Systems
Water Resources ResearchPressure and flow estimation in water distribution networks (WDNs) allows water management companies to optimize their control operations. For many years, mathematical simulation tools have been the most common approach to reconstructing an estimate of ...
Huy Truong +3 more
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Engineering Applications of Computational Fluid MechanicsSafe drinking water is essential to public health and social stability. Despite advances in modern materials and design, water distribution systems (WDSs) remain vulnerable to failure.
Minhyuk Jeung +3 more
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