Results 61 to 70 of about 11,715,296 (244)
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Operational optimization of water distribution networks using hybrid algorithms
, 2010 Operation of water system distribution involves utilisation of pumps, tanks, and storages for the purpose of providing good quality water to costumers at a reasonable flow and pressure. Optimal operation of a water distribution system aims
Ngandu, B.
core
Optimum Layout for Sensors in Water Distribution Networks through Ant Colony Algorithm: A Dual Use Vision [PDF]
آب و فاضلاب, 2014 The accidental or intentional entry of contaminants or self-deterioration of the water quality within the network itself can severely harm public health.
Seyed Mehdi Miri, Abbas Afshar
doaj
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
, 2007 The reliability assessment of water distribution systems is a complicated process. Manyresearchers have tried to devise methods to come up with indices that represent theperformance of water distribution networks.
Temam, R.A.
core
Decision model to control water losses in distribution networks
Production, 2016 The losses in the urban water supply networks have become a growing concern. There are several alternatives for the quantification, detection and monitoring of water losses.
Marcele Elisa Fontana +1 more
doaj +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Estimation of Hydraulic Pressure in Water Networks Using Artificial Neural Networks and Fuzzy Logic [PDF]
آب و فاضلاب, 2005 Hydraulic pressure is one of the most significant parameters in optimizing water distribution networks. Its simulation and estimation are essential tools in water distribution network management due to the significant effects it has on certain parameters
Mohammad Karamouz +3 more
doaj
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source