Results 71 to 80 of about 238,040 (312)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Electricity Distribution Networks: Investment and Regulation, and Uncertain Demand

, 2011
Electricity distribution networks are capital intensive systems and timely investments are crucial for long-term reliability of their service. In coming years, in the UK, and elsewhere in Europe, many networks are in need of extensive investments in ...
Jamasb, Tooraj., Marantes, C
core   +1 more source

Physics-Informed Machine Learning for Universal Surrogate Modelling of Water Quality Parameters in Water Distribution Networks

Engineering Proceedings
Modelling and assessing water quality parameters in water distribution networks is essential for providing safe drinking water to end users. While simulation-based modeling approaches rely on costly differentiation for numerical solvers, surrogate models
Ivo Daniel, Gopinathan R. Abhijith, J. Nathan Kutz, Avi Ostfeld, Andrea Cominola   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Methodology to optimally place pressure sensors for leak detection in water distribution systems using value of information and entropy

, 2021
The presence of leaks in water distribution networks (WDN) is a very common problem that impacts these systems in a variety of ways, including the loss of drinking water, the deterioration of the quality of supply water due to the intrusion of substances
López García, Edgar Andrés
core   +1 more source

Improvement of water distribution networks analysis by topological similarity

Alexandria Engineering Journal, 2016
In this research paper a methodology based on topological similarity is used to obtain starting point of iteration for solving reservoir and pipe network problems.
Mahavir Singh, Suraj Krishan Kheer, I.K. Pandita   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Leakage detection in water distribution networks using machine-learning strategies

, 2023
This work proposes a reliable leakage detection methodology for water distribution networks (WDNs) using machine-learning strategies. Our solution aims at detecting leakage in WDNs using efficient machine-learning strategies.
Charles Casimiro Cavalcante, Barros da Silva Jr., José Mairton,, Du, Rong,, José Mairton Barros da Silva Jr, Sousa, Diego Perdigão,, Cavalcante, Charles Casimiro, Du, Rong, Carlo Fischione, Cavalcante, Charles Casimiro,, Sousa, Diego Perdigão, Barros da Silva Junior, Jose Mairton, Fischione, Carlo, Diego Perdigão Sousa, Fischione, Carlo,, Rong Du, Barros da Silva Junior, Jose Mairton,   +15 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source