Results 61 to 70 of about 3,013,990 (285)

On the need for a global engineering initiative to mitigate climate change [PDF]

, 2016
There is growing scientific evidence that the continued emission of greenhouse gases will eventually lead to catastrophic irreversible climate change and that, therefore, a global effort needs to be started to transition to a fully renewable economy.
Platzer, Max F.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Advancing Water Sustainability: Innovative Technologies in Hydrology and Water Resources Engineering [PDF]

E3S Web of Conferences
In the evolving field of water environment, hydrology, and water resources engineering, advanced water treatment techniques have emerged as pivotal elements in addressing contemporary challenges and ensuring sustainable water management.
Liu Xu
doaj   +1 more source

Raising irrigation productivity and releasing water for intersectoral needs (RIPARWIN): RIPARWIN final technical report [PDF]

River basinsHydrologyRiver basin managementRiver basin developmentDevelopment projectsWater allocationIrrigation waterProductivityIrrigation managementRiceTanzaniaGreat Ruaha River BasinUsangu River ...
International Water Management Institute (IWMI) Africa Regional Office, Sokoine University of Agriculture, Department of Agricultural Engineering, Soil Water Research Group, University of East Anglia, Overseas Development Group   +2 more
core  

Water resources development: engineering the future of global health [PDF]

, 2013
This repository item contains a single issue of Issues in Brief, a series of policy briefs that began publishing in 2008 by the Boston University Frederick S. Pardee Center for the Study of the Longer-Range Future.Pardee 2012 Summer Graduate Fellow Diana
Gergel, Diana
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Spatio-temporal evolution of water engineering facilities and social influences on the Grand Canal during the Ming and Qing dynasties

Heritage Science
This research explores the spatial distribution patterns of water engineering facilities along the Grand Canal during the Ming and Qing dynasties. It employs the entropy method to assess the social development status of prefectures during these periods ...
Wang Cheng, Tan Lifeng, Wang Guanhua, Li Liang, Qiu Xin, Zhang Yiwen   +5 more
doaj   +1 more source

Membrane modification strategies for virus removal from water

iScience
Summary: Membrane technology, through innovative approaches such as nanocomposite membranes, membrane bioreactors, and electrocatalytic membrane reactors, offers a synergistic platform for pathogen removal.
Yang Li, Xueye Wang, Lehui Ren, Ruobin Dai, Zhiwei Qiu, Huimin Zhou, Zhiwei Wang   +6 more
doaj   +1 more source