Results 81 to 90 of about 3,013,990 (285)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Construction of water supply and drainage engineering
MATEC Web of Conferences, 2018 Construction of water supply and drainage engineering is one of the main special courses offered to students whose major is Water Supply and Drainage. Through learning of this course, the students should understand earth and rock works, water drainage in
Zhang Haiying
doaj +1 more source
Quality requirements for reclaimed/recycled water [PDF]
Water used during current and previous space missions has been either carried or made aloft. Future human space endeavors will require some form of water reclamation and recycling. There is little experience in the U.S. space program with this technology.
Janik, Daniel S. +3 more
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Water Quality System Informatics: An Emerging Inter-Discipline of Environmental Engineering
EngineeringWater quality system informatics (WQSI) is an emerging field that employs cybernetics to collect and digitize data associated with water quality. It involves monitoring the physical, chemical, and biological processes that affect water quality and the ...
Hong Liu +6 more
doaj +1 more source
Ecology and Society, 2010 Broad-scale, multi-governance level, participatory water management processes intended to aid collective decision making and learning are rarely initiated, designed, implemented, and managed by one person.
Katherine A. Daniell +11 more
doaj +1 more source
An Interdisciplinary Approach for the Assessment and Implementation of Resilient and Flexible Water Supply Infrastructure under Changing or Instable Conditions [PDF]
, 2015 In case of demographic changes or emergencies pipeline bound infrastructure like gas or water is specifically challenged. Then, the advantages of decentralized infrastructure should be considered: Minimization of asset bound funds; flexibility ...
Günthert, F.W., Walter, W.K.
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Modeling and analysis of pooled stepped chutes [PDF]
, 2010 We consider an application of pooled stepped chutes where the transport in each pooled step is described by the shallow--water equations. Such systems can be found for example at large dams in order to release overflowing water.
Guerra, Graziano +2 more
core +1 more source