Results 101 to 110 of about 936,045 (302)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effects of the Hydrology-Water Chemistry Factors of the Xijiang River Basin on the Carbon Sink Flux in the Karst System

Yankuang ceshi, 2016
The river carbon sink flux is important for the global carbon cycle and finding the missing carbon sink. Hydrogeological features are important parts of the karst dynamic system.
HUANG Jie, YU Shi, LUO Hui-xian, LIN Dan-hui   +3 more
doaj   +1 more source

Microwave hydrology: A trilogy [PDF]

Microwave hydrology, as the term in construed in this trilogy, deals with the investigation of important hydrological features on the Earth's surface as they are remotely, and passively, sensed by orbiting microwave receivers.
Girard, M. A., Johnston, E. J., Regusters, H. A., Stacey, J. M.   +3 more
core   +1 more source

Coupling of ion and water fluxes in synthetic membranes*

Journal of Membrane Science, 1980
When the salt fluxes across a fixed charge membrane predicted by the Teorell-Meyer-Sievers (TMS) theory are compared with experiment it is found that in low-resistance ion-exchange membranes the coupling of ion and water fluxes should be taken into account.
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Synergistic Effect of Ca²⁺ and SO₄^2- Ions and Gypsum Scaling in Feed Solution on Forward Osmosis Boron Removal

Chemical Engineering Transactions, 2018
This paper investigates the synergistic effect of Ca2+ and SO42- ions in feed solution on the forward osmosis (FO) removal of boron by a thin-film, composite membrane with embedded supports of polyester screens (TFC-ES). Specifically, water flux, reverse
Yi Wang, Hao Guo, Lubin Chen, Chaoxin Xie, Ningyu Zhou, Zhendong Fang   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Influence of Bamboo Cellulose Coating on the Flux Performance of Polyvinylidene Fluoride Hollow Fiber Membrane

BioResources
This study showcases the characterization of a surface modified polyvinylidene fluoride (PVDF) hollow fiber membrane via Cellulose/PVDF coating. Scanning electron microscopy shows evidence of Cellulose/PVDF coating where surface roughness and coating ...
Perry Law Nyuk Khui, Md Rezaur Rahman, Khairul Anwar bin Mohamad Said, Murtala Namakka, M. Shahabuddin, Muneera S. M. Al-Saleem, Jehan Y. Al-Humaidi, Mohammed M. Rahman, King Kuok Kuok   +8 more
doaj  

Technique for assessing vegetation-induced moisture flux, with implications for global climate modeling [PDF]

The time between storms, the duration of storms, and the storm depths are studied in relation to vegetation controls on the disposition of rainfall.
Macari, Emir Jose
core   +1 more source