Results 111 to 120 of about 7,416,707 (356)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Simulation of upward flux from shallow water-table using UPFLOW model

, 2013
The upward movement of water by capillary rise from shallow water-table to the root zone is an important incoming flux. For determining exact amount of irrigation requirement, estimation of capillary flux or upward flux is essential. Simulation model can
Ali, M.H., Abustan, I., M. H. Ali, Islam, S., S. Islam, I. Abustan   +5 more
core   +1 more source

Effects of the Hydrology-Water Chemistry Factors of the Xijiang River Basin on the Carbon Sink Flux in the Karst System

Yankuang ceshi, 2016
The river carbon sink flux is important for the global carbon cycle and finding the missing carbon sink. Hydrogeological features are important parts of the karst dynamic system.
HUANG Jie, YU Shi, LUO Hui-xian, LIN Dan-hui   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Optimisation of membrane technology for water reuse [PDF]

, 2011
Increasing freshwater scarcity is making reclamation of wastewater effluent more economically attractive as a means of preserving freshwater resources.
Raffin, Marie
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Measurement and parameterisation of the air-sea CO2 flux in high winds

, 2011
During a three year occupation of Station Mike (66°N 2°E), the Norwegian Ocean Weather Ship Polarfront was equipped with a range of meteorological and seastate measuring instruments, including the autonomous air-sea flux system “AutoFlux” (Yelland et al.,
Prytherch, John
core  

Synergistic Effect of Ca²⁺ and SO₄^2- Ions and Gypsum Scaling in Feed Solution on Forward Osmosis Boron Removal

Chemical Engineering Transactions, 2018
This paper investigates the synergistic effect of Ca2+ and SO42- ions in feed solution on the forward osmosis (FO) removal of boron by a thin-film, composite membrane with embedded supports of polyester screens (TFC-ES). Specifically, water flux, reverse
Yi Wang, Hao Guo, Lubin Chen, Chaoxin Xie, Ningyu Zhou, Zhendong Fang   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

2D kaolin ultrafiltration membrane with ultrahigh flux for water purification

, 2019
Membrane separation technology is an important option for the treatment of contaminated surface waters but the relatively high cost of materials and membrane fabrication represent a significant obstacle to the wider use of membrane processes.
Graham, Nigel, Sun, Kening, Zhou, Huimin, Yu, Wenzheng, Liu, Ting   +4 more
core   +1 more source