Results 81 to 90 of about 936,045 (302)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Imaging Oxygen Distribution in Marine Sediments. The Importance of Bioturbation and Sediment Heterogeneity [PDF]

, 2008
The influence of sediment oxygen heterogeneity, due to bioturbation, on diffusive oxygen flux was investigated. Laboratory experiments were carried out with 3 macrobenthic species presenting different bioturbation behaviour patterns:the polychaetes ...
AK Hannides, AL Freestone, B Thamdrup, BB Jorgensen, BJ Cardinale, DC Rhoads, E Kristensen, E Kristensen, E Kristensen, E Kristensen, E Kristensen, E Michaud, E Michaud, EJ Gustafson, ER Trueman, F François, F François, F Gilbert, F Mermillod-Blondin, F Talin, F. Gilbert, H Kautsky, H Li, H Rasmussen, J Tardy, J. C. Poggiale, JC Poggiale, JT Davey, L. Pischedda, M Gérino, M Gérino, ML Cadenasso, NP Revsbech, NP Revsbech, P Berg, P Duttilleul, P. Cuny, PVR Snelgrove, QZ Zhu, RA Berner, RC Aller, RC Aller, RC Aller, RL Foster-Smith, RN Glud, RV O’Neill, S Garrigues, S Hulth, SC Dufour, TH Pearson   +49 more
core   +4 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Modeling impacts of farming management alternatives on CO2, CH4, and N2O emissions: A case study for water management of rice agriculture of China [PDF]

, 2005
Since the early 1980s, water management of rice paddies in China has changed substantially, with midseason drainage gradually replacing continuous flooding.
Boles, Stephen, Frolking, Steve, Huang, Yao, Li, Changsheng, Moore, B, Qiu, Jianjun, Salas, William A, Sass, Ronald, Xiao, Xiangming   +8 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Stem-root flow effect on soil–atmosphere interactions and uncertainty assessments [PDF]

, 2015
. Soil water can rapidly enter deeper layers via vertical redistribution of soil water through the stem–root flow mechanism. This study develops the stem–root flow parameterization scheme and coupled this scheme with the Simplified Simple Biosphere model
Chen, J-P, Kuo, T-H, Xue, Y
core   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Blue, white, and red ocean planets - Simulations of orbital variations in flux and polarization colors

, 2019
An exoplanet's habitability will depend strongly on the presence of liquid water. Flux and/or polarization measurements of starlight that is reflected by exoplanets could help to identify exo-oceans.
Stam, Daphne M., Trees, Victor J. H.
core   +1 more source

Use of water from small alluvial aquifers for irrigation in semi-arid regions. [PDF]

, 2011
Water from small alluvial aquifers constitutes an attractive and low-cost option for irrigation and rural development in Northeastern Brazil. Based on piezometric measurements, geochemical analyses and electrical conductivity estimates, the present case ...
Burte, Julien Daniel Pierre, Coudrain, Anne, Marlet, Serge   +2 more
core   +4 more sources