Results 71 to 80 of about 936,045 (302)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Novel draw solutes of iron complexes easier recovery in forward osmosis process
Journal of Water Reuse and Desalination, 2018 Forward osmotic (FO) membrane is a new process for producing fresh water from salt water. The study of draw solute is essential in the development and application of FO technology; draw solution should be good at drawing water and easy at recovery.
Nguyen Quang Trung +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Why current-carrying magnetic flux tubes gobble up plasma and become thin as a result [PDF]
, 2003 It is shown that if a current-carrying magnetic flux tube is bulged at its axial midpoint z=0 and constricted at its axial endpoints z=+h,-h, then plasma will be accelerated from z=+h,-h towards z=0 resulting in a situation similar to two water jets ...
P. M. Bellan +2 more
core +3 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Neutron Flux at the Gran Sasso Underground LaboratoryRevisited
, 2004 The neutron flux induced by radioactivity at the Gran Sasso underground laboratory is revisited. We have performed calculations and Monte Carlo simulations; the results offer an independent check to the available experimental data reported by different ...
Aleksan +16 more
core +1 more source
3D climate modeling of close-in land planets: Circulation patterns, climate moist bistability and habitability [PDF]
, 2013 The inner edge of the classical habitable zone is often defined by the critical flux needed to trigger the runaway greenhouse instability. This 1D notion of a critical flux, however, may not be so relevant for inhomogeneously irradiated planets, or when ...
A. Spiga +6 more
core +3 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Metastable State of Water and Performance of Osmotically Driven Membrane Processes
Membranes, 2019 Semipermeable membranes play critical roles in many natural and engineering systems. The osmotic pressure is found experimentally much less effective than the hydraulic pressure to drive water through the membrane, which is commonly attributed to the ...
Haifeng Zhang +3 more
doaj +1 more source
Hydrologically transported dissolved organic carbon influences soil respiration in a tropical rainforest [PDF]
Biogeosciences, 2016 To better understand the effect of dissolved organic carbon (DOC) transported by hydrological processes (rainfall, throughfall, litter leachate, and surface soil water; 0–20 cm) on soil respiration in tropical rainforests, we detected the DOC flux in ...
W.-J. Zhou +7 more
doaj +1 more source