Results 141 to 150 of about 7,416,707 (356)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Monitoring Perched Ground Water in the Vadose Zone

open access: yes, 1978
American Water Resources Association Symposium Proceedings / Reprinted from Establishment of Water Quality Monitoring Programs / Edited By: Lorne G. Everett and Kenneth D.
Wilson, L. G., Schmidt, K. D.
core  

Single-phase flow and flow boiling of water in horizontal rectangular microchannels [PDF]

open access: yes, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel UniversityThe current study is part of a long term experimental project devoted to investigating single-phase flow pressure drop and heat transfer, flow boiling ...
Mirmanto
core  

Diagnosing the stratosphere-to-troposphere flux of ozone in a chemistry transport model [PDF]

open access: yes, 2005
[1] Events involving stratosphere-troposphere exchange (STE) of ozone, such as tropopause folds and westerly ducts, are readily identified in observations and models, but a quantitative flux specifying where and when stratospheric ozone is mixed into the
Hsu, Juno   +7 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Forced boiling of nanofluids, effects of contact angle and surface wettability

open access: yes, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
Haghshenas Fard, M   +4 more
core  

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Post–Synthetic Modification of MOF–808 for Mixed Matrix Membranes with High and Stable Ion Separation Capacity

open access: yesMolecules
The global clean water crisis is a pressing sustainable development challenge that demands urgent solutions. Membrane separation technology has emerged as a leading approach for seawater desalination, offering great potential to address freshwater ...
Bahar Karadeniz   +5 more
doaj   +1 more source

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