Results 121 to 130 of about 28,076 (308)
Ecotoxicology and Environmental SafetyThe Water Framework Directive (WFD, 2000/60/EC) mandates member states to consider trace element background values when establishing environmental quality standards (EQS) for sediments.
F. Barrio-Parra +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
River basin management and the Water Framework Directive: in need of a little HELP? [PDF]
, 2008 This article examines the progress of the WFD, and particularly river basin planning, in the context of wider policy for water resources management, and in relation to the pre-existing initiative of the global UNESCO programme, Hydrology, Environment ...
Hendry, Sarah; id_orcid
core
Editorial: European water framework directive [PDF]
Proceedings of the Institution of Civil Engineers - Water Management, 2011 Hartnett, Michael, Stamou, Anastasios I.
openaire +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A Multi-Criteria Approach for Irrigation Water Management
The major implications that the European Union (EU) Water Framework Directive (WFD) may have in irrigated agriculture were analysed using alternative water policy measures. The consequences of policy change were evaluated in a case study (Baixo Alentejo,
Pinheiro, Antonio Cipriano +1 more
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An Assessment of the Performance of the PLUS+ Tool in Supporting the Evaluation of Water Framework Directive Compliance in Scottish Standing Waters. [PDF]
Int J Environ Res Public Health, 2020 Donnelly D +3 more
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source