Results 121 to 130 of about 28,100 (309)

A spatial assessment model for European eel (Anguilla anguilla) in a delta, The Netherlands

open access: yesKnowledge and Management of Aquatic Ecosystems, 2013
Given the poor status of the European eel (Anguilla anguilla) population, good assessments are essential to optimise recovery measures. Quantifying eel stock size is challenging given the fractal nature of the distribution of eels,
Van De Wolfshaar K.E.   +4 more
doaj   +1 more source

Editorial: European water framework directive [PDF]

open access: yesProceedings of the Institution of Civil Engineers - Water Management, 2011
Hartnett, Michael, Stamou, Anastasios I.
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

A proposed methodology for the definition of background and reference values for trace elements in fluvial sediments

open access: yesEcotoxicology and Environmental Safety
The Water Framework Directive (WFD, 2000/60/EC) mandates member states to consider trace element background values when establishing environmental quality standards (EQS) for sediments.
F. Barrio-Parra   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Water Framework Directive - integration, negotiation and communication of optimal measures with stakeholders (WINCOMS) : STRIVE report [PDF]

open access: yes, 2006
Paper presented at the Man and River Systems II: Interactions among rivers, their watersheds and the sociosystem Symposium, Paris, 4-6 December 2006Other funderEnvironmental Protection AgencyNational Development PlanStrategy for Science Technology and ...
Bryan, S.   +6 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Which economic model for a water-efficient Europe? Report of a CEPS Task Force. CEPS Task Force Report, 27 November 2012 [PDF]

open access: yes, 2012
This CEPS Task Force Report focuses on how to improve water efficiency in Europe, notably in public supply, households, agriculture, energy and manufacturing as well as across sectors.
Núñez Ferrer, Jorge   +3 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

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