Results 111 to 120 of about 28,100 (309)
A journey towards whole water certified reference materials for organic substances: measuring polycyclic aromatic hydrocarbons as required by the European Union Water Framework Directive. [PDF]
Anal Bioanal Chem, 2021 Dosis I, Ricci M, Emteborg H, Emons H.
europepmc +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Spatial Sampling Strategies for Assessing Public Opinion Under the Water Framework Directive: A Case Study of the Ythan Project [PDF]
Consultation with and inclusion of the public on measures to manage and improve water resources is a key tenet of the Water Framework Directive (WFD).
Neil Sang
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Frontiers in Marine Science, 2019 Increased nutrient delivery to estuarine systems results in elevated growth of primary producers. This is evidenced by high chlorophyll concentrations and increased frequency of phytoplankton blooms.
Sorcha Ní Longphuirt +4 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Phytoplankton in the ecological status assessment of European lakes – advantages and constraints
Environmental Protection and Natural Resources, 2016 Although the phytoplankton indices describing the response of phytoplankton to the eutrophication have been developed and used for many years in the routine lake monitoring programme in some countries, the implementation of the Water Framework Directive (
Pasztaleniec Agnieszka
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Potential groundwater and surface water contamination from nitrate in the Po River Delta (Northern Italy): results from an applied research within the Water Framework Directive [PDF]
, 2009 Nitrogen losses from agricultural sources have been recognised as one of the most serious threats in industrialised and emerging countries, determining ecosystem eutrophication and groundwater nitrate contamination.
S. Bolognesi +7 more
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Людина і довкілля: Проблеми неоекологіїPurposes. Development of scientifically based proposals for taking into account the conditions of the Water Framework Directive of the European Union and river basin management plans when calculating maximum permissible discharges of pollutants with ...
S. M. Yurasov, V. V. Terzeman
doaj +1 more source