Results 101 to 110 of about 28,100 (309)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Groundwater quality trend and trend reversal assessment in the European Water Framework Directive context: an example with nitrates in Italy. [PDF]

Environ Sci Pollut Res Int, 2021
Frollini E, Preziosi E, Calace N, Guerra M, Guyennon N, Marcaccio M, Menichetti S, Romano E, Ghergo S.   +8 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Water Policy and Sustainability of Irrigated Farming Systems in Italy [PDF]

The objective of this paper is to provide an analysis of the sustainability of irrigated agriculture in Italy in the context of CAP reform and Water Framework Directive.
Viaggi, Davide, Bazzani, Guido Maria, Gallerani, Vittorio, Bartolini, Fabio, Raggi, Meri   +4 more
core   +1 more source

Land-use and agriculture in Denmark around year 1900 and the quest for EU Water Framework Directive reference conditions in coastal waters. [PDF]

Ambio, 2021
Christensen BT, Pedersen BF, Olesen JE, Eriksen J.   +3 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The environment as a challenge for governmental responsibility: The case of the European Water Framework Directive [PDF]

The European Water Framework Directive is shaping a new conception of integrative water protection. In this article, the consequences of the Water Framework Directive in respect to national environmental policy will be discussed in referring to the ...
Petersen, Thomas, Manstetten, Reiner, Klauer, Bernd   +2 more
core  

Practical Experiences from Existing Case Studies and Pilot River Basins [PDF]

, 2010
Water resources planning and management and the development of appropriate policies requires methodologies and tools that are able to support systematic, integrative and multidisciplinary assessments at various scales. It also requires the quantification
Hatterman, F.F, Stålnacke, P, Kaden, S, Laurens, Y, Kundzewicz, Z.W., Willems, P, Castelletti, G, Muhar, S, Becker, A, Gooch, Geoffrey,, Soncini-Sessa, R, Pahl-Wostl, Claudia   +11 more
core  

New directions in water resources management: The role of water pricing policies [PDF]

, 2008
Water resources will face increasing competition and higher environmental concerns during this century. To meet these challenges, the new Water Framework Directive has drawn up an integrated framework and established the basic principles for a ...
Blanco Fonseca, Maria, Iglesias Martínez, Eva   +1 more
core   +2 more sources

Measures for Improving the Aquatic Biodiversity on the Lower Sector of Bega Veche River [PDF]

Aerul şi Apa: Componente ale Mediului
For surface water bodies, the main environmental objectives set out in the Water Framework Directive are aimed at achieving the good ecological status, respectively the good potential for heavily modified and artificial water bodies.
L. STAN, D. RĂDULESCU, R. CIOBANU, C. RIZEA, S. NEAȚU, M. A. GHIȚESCU   +5 more
doaj   +1 more source