Results 91 to 100 of about 28,100 (309)

Studying the implementation of the Water Framework Directive in Europe: a meta-analysis of 89 journal articles

Ecology and Society, 2016
The Water Framework Directive (WFD) is arguably the most ambitious piece of European Union (EU) legislation in the field of water. The directive defines a general framework for integrated river basin management in Europe with a view to achieving "good ...
Blandine Boeuf, Oliver Fritsch
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Water cycle strategy process and its application [PDF]

, 2008
Water Cycle Strategies (WCS) have been developed for various areas of the UK. WCSs gather an evidence base which should assist with the promotion of sustainable water management and compliance with important legislation such as the Water Framework ...
Cvejic, Rozalija
core  

Opportunities to tackle antibiotic resistance development in the aquatic environment through the Water Framework Directive. [PDF]

Ambio, 2023
Ågerstrand M, Josefsson H, Wernersson AS, Larsson DGJ.   +3 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Multi-Criteria Approach for Irrigation Water Management [PDF]

The major implications that the European Union (EU) Water Framework Directive (WFD) may have in irrigated agriculture were analysed using alternative water policy measures. The consequences of policy change were evaluated in a case study (Baixo Alentejo,
Pinheiro, Antonio Cipriano, Saraiva, Joao Paulo   +1 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Agroecological soil evaluation for monitoring water quality using microleis DSS [PDF]

, 2011
Soil degradation has both indirect and direct effects on the quality of surface and ground waters. In this sense, agriculture is one of the key activities causing water quality degradation in many parts of Mediterranean systems.
Rosa, Diego de la, Kotb Abd-Elmabod, Sameh   +1 more
core  

Identifying uncertainty guidelines for supporting policy making in water management illustrated for Upper Guadiana and Rhine Basins [PDF]

, 2010
In recent years, guidelines have been developed for supporting water managers in dealing with uncertainty in integrated water resources management (IWRM).
Lamers, M.A.J., Lamers, M., Refsgaard, J.C., Poolman, M.I., Warmink, J.J., Mysiak, J., van der Keur, P., Zorilla, P., Henriksen, H.J., Mysiak, J, Isendahl, N, Raadgever, G.T., Brugnach, M., van der Keur, P, Poolman, M, Poolman, M., Keur, P., van der, De Wulf, A., Zorilla, P, Dewulf, A., Isendahl, N., DeWulf, A, Brugnach, M   +22 more
core   +1 more source

Incorporating Ecosystem Services in the Assessment of Water Framework Directive Programmes of Measures. [PDF]

Environ Manage, 2021
Souliotis I, Voulvoulis N.
europepmc   +1 more source