Results 91 to 100 of about 28,076 (308)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Agroecological soil evaluation for monitoring water quality using microleis DSS [PDF]

, 2011
Soil degradation has both indirect and direct effects on the quality of surface and ground waters. In this sense, agriculture is one of the key activities causing water quality degradation in many parts of Mediterranean systems.
Rosa, Diego de la, Kotb Abd-Elmabod, Sameh   +1 more
core  

Identifying uncertainty guidelines for supporting policy making in water management illustrated for Upper Guadiana and Rhine Basins [PDF]

, 2010
In recent years, guidelines have been developed for supporting water managers in dealing with uncertainty in integrated water resources management (IWRM).
Lamers, M.A.J., Lamers, M., Refsgaard, J.C., Poolman, M.I., Warmink, J.J., Mysiak, J., van der Keur, P., Zorilla, P., Henriksen, H.J., Mysiak, J, Isendahl, N, Raadgever, G.T., Brugnach, M., van der Keur, P, Poolman, M, Poolman, M., Keur, P., van der, De Wulf, A., Zorilla, P, Dewulf, A., Isendahl, N., DeWulf, A, Brugnach, M   +22 more
core   +1 more source

Incorporating Ecosystem Services in the Assessment of Water Framework Directive Programmes of Measures. [PDF]

Environ Manage, 2021
Souliotis I, Voulvoulis N.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Groundwater quality trend and trend reversal assessment in the European Water Framework Directive context: an example with nitrates in Italy. [PDF]

Environ Sci Pollut Res Int, 2021
Frollini E, Preziosi E, Calace N, Guerra M, Guyennon N, Marcaccio M, Menichetti S, Romano E, Ghergo S.   +8 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Land-use and agriculture in Denmark around year 1900 and the quest for EU Water Framework Directive reference conditions in coastal waters. [PDF]

Ambio, 2021
Christensen BT, Pedersen BF, Olesen JE, Eriksen J.   +3 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The environment as a challenge for governmental responsibility: The case of the European Water Framework Directive [PDF]

The European Water Framework Directive is shaping a new conception of integrative water protection. In this article, the consequences of the Water Framework Directive in respect to national environmental policy will be discussed in referring to the ...
Petersen, Thomas, Manstetten, Reiner, Klauer, Bernd   +2 more
core