Results 71 to 80 of about 28,076 (308)

Implementation of the Water Framework Directive in Italy: state of the art and selected research issues [PDF]

, 2010
The Water Framework Directive (WFD) was implemented rather late in Italy. The actual implementation took place in 2006 with decree 152/2006 but the Directive was not completely effective until the beginning of 2009, when law 13/2009 provided for the ...
Raggi, M., Ronchi, D., SARDONINI, LAURA, Sardonini, L., RAGGI, MERI, Viaggi, D., RONCHI, DAVIDE, VIAGGI, DAVIDE   +7 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Potential Implications of the EU Water Framework Directive in Sweden

European Journal of Spatial Development, 2005
The Water Framework Directive (WFD) is currently being implemented throughout Europe. As the Directive is likely to introduce major changes to the way in which water is managed in Sweden, this study aims to highlight some of the potential implications ...
Beatrice Hedelin
doaj   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Conceptualising uncertainty in environmental decision-making: The example of the EU Water Framework Directive [PDF]

The question of how to deal with uncertainty in environmental decision-making is cur-rently attracting considerable attention on the part of scientists as well as of politicians and those involved in government administration.
Sigel, Katja, Klauer, Bernd, Pahl-Wostl, Claudia   +2 more
core  

Studying the implementation of the Water Framework Directive in Europe: a meta-analysis of 89 journal articles

Ecology and Society, 2016
The Water Framework Directive (WFD) is arguably the most ambitious piece of European Union (EU) legislation in the field of water. The directive defines a general framework for integrated river basin management in Europe with a view to achieving "good ...
Blandine Boeuf, Oliver Fritsch
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The EU Water Framework Directive twenty years on: Introducing the Special Issue

Water Alternatives, 2020
Twenty years ago, the European Union launched one of its flagship environmental regulations, the Water Framework Directive (WFD). Since its inception in 2000, the WFD has been a guiding light for water professionals within and beyond the EU; it has ...
Timothy Moss, Gabrielle Bouleau, José Albiac, Lenka Slavíkova   +3 more
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Development of innovative tools for understanding marine biodiversity and assessing good environmental status: the EU project DEVOTES [PDF]

, 2012
AZTI-Tecnalia organized the XVII edition of SIEBM – Iberian Symposium on Marine Biology Studies, in Donostia – San Sebastián, from 11th to 14th September 2012.
Borja, Àngel
core   +1 more source