Results 61 to 70 of about 28,076 (308)
Modelling soil phosphorus decline: Expectations of Water Framework Directive policies
, 2010 Depletion of plant-available soil phosphorus (P) from excessive to agronomically optimum levels is a measure being implemented in Ireland to reduce the risk of diffuse P transfer from land to water.
A.R. Melland +11 more
core +1 more source
Remote Sensing, 2018 The European Parliament and The Council of the European Union have established the Water Framework Directive (2000/60/EC) for all European Union member states to achieve, at least, “good” ecological status of all water bodies larger than 50 ...
Ave Ansper, Krista Alikas
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Frontiers in Marine Science, 2016 This paper presents a typology of stakeholders for effective participatory processes and co-design of solutions to complex social-environmental issues and a roadmap stepwise methodology for balanced and productive stakeholder engagement.
Alice Newton +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Law policy of European Union in the sphere of water conservation
Проблеми Законності, 2017 In the light of such foreign policy goal as accession to the EU there was arised a need to thorough research of European Union’s water policy and legislation with the view of its adaptation to the national legislation. The basic issues of European Union’
Марина Костянтинівна Черкашина
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Water Framework Directive Article 7, The Drinking Water Directive and European Pesticide Regulation: impacts on diffuse pesticide pollution, potable water decision making and catchment management strategy [PDF]
, 2013 The European Water Framework Directive (WFD) promotes increased awareness of catchment processes and challenges the established dependence on a ‘treatment-led approach’ for the supply of European Drinking Water Directive (DWD) compliant potable water. In
Dolan, Tom
core
Utrecht Law Review, 2014 Over the years, the polluter pays principle has developed into a strong basis for EU policy making. Many European Directives refer to this principle, for instance as a basis for cost recovery or liability.
Petra E. Lindhout, Berthy van den Broek
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source