Results 81 to 90 of about 28,076 (308)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
A review: Macrophytes in the assessment of Spanish lakes ecological status under the Water Framework Directive (WFD) [PDF]
, 2010 Basándose en que los procesos de biomonitorización aportan información muy valiosa sobre los impactos en organismos y consecuentemente en el estado ecológico de los ecosistemas, la Directiva Marco del Agua (WFD; Unión Europea, 2000) incorpora el uso de ...
Toro, Manuel +3 more
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Marine macrophytes and the Water Framework Directive: preliminary studies in southern Spain [PDF]
, 2010 The Water Framework Directive (WFD) includes angiosperms and macroalgae as biological quality elements (BQE) for coastal and transitional waters. In southern Spain (Andalusia), studies to implement the WFD using angiosperms (seagrasses) started in June ...
Hernández, Ignacio +4 more
core
Sensors, 2010 This review discusses from a critical perspective the development of new sensors for the measurement of priority pollutants targeted in the E.U. Water Framework Directive.
Nicole Jaffrezic-Renault +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Water cycle strategy process and its application [PDF]
, 2008 Water Cycle Strategies (WCS) have been developed for various areas of the UK. WCSs gather an evidence base which should assist with the promotion of sustainable water management and compliance with important legislation such as the Water Framework ...
Cvejic, Rozalija
core
Opportunities to tackle antibiotic resistance development in the aquatic environment through the Water Framework Directive. [PDF]
Ambio, 2023 Ågerstrand M +3 more
europepmc +1 more source
Environmental Law Review, 2018 The Environmental Liability Directive (ELD) focuses on remediating environmental damage. To assess environmental damage it uses existing assessment systems, and the constructs that are at the centre of these systems. One of these is ‘ecological status’ in the context of the Water Framework Directive (WFD). The ELD refers to the WFD with respect to what
openaire +3 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source