Results 131 to 140 of about 28,100 (309)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

River basin management and the Water Framework Directive: in need of a little HELP? [PDF]

, 2008
This article examines the progress of the WFD, and particularly river basin planning, in the context of wider policy for water resources management, and in relation to the pre-existing initiative of the global UNESCO programme, Hydrology, Environment ...
Hendry, Sarah; id_orcid
core  

The Water Framework Directive could be the Key

Ökologisches Wirtschaften - Fachzeitschrift, 2003
Die Wasserrahmenrichtlinie ist eine der wichtigsten neuen EU-Richtlinien im Hin­blick auf eine nachhaltige Entwicklung. Auch in den Beitrittsländern sind die Vorbe­reitungen zur Übernahme in vollem Gange. Da das Management von Wasserres­sourcen in unmittelbarem Zusammenhang mit Fragen der Landnutzung und der all­gemeinen wirtschaftlichen Entwicklung ...
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Modelling Agricultural Diffuse Pollution: CAP – WFD Interactions and Cost Effectiveness of Measures [PDF]

Within the context of the Water Framework Directive (WFD) and the Common Agricultural Policy (CAP), the design of effective and sustainable agricultural and water resources management policies presents multiple challenges.
Moran, Dominic, Mouratiadou, Ioanna, Topp, Cairistiona   +2 more
core   +1 more source

An Assessment of the Performance of the PLUS+ Tool in Supporting the Evaluation of Water Framework Directive Compliance in Scottish Standing Waters. [PDF]

Int J Environ Res Public Health, 2020
Donnelly D, Helliwell RC, May L, McCreadie B.   +3 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Agricultural water markets: exploring limits and opportunities in Italy and Spain [PDF]

Agriculture is the main water-using sector in Southern European Countries, such as Spain and Italy. Innovative institutional solutions for reducing water use or increasing its efficiency are pursued by recent legislation concerning water, in particular ...
Joan Pujol, Davide Viaggi, Meri Raggi
core