Groundwater research and management: integrating science into management decisions. Proceedings of IWMI-ITP-NIH International Workshop on "Creating Synergy Between Groundwater Research and Management in South and Southeast Asia," Roorkee, India, 8-9 February 2005 [PDF]
Groundwater management / Governance / Groundwater development / Artificial recharge / Water quality / Aquifers / Groundwater irrigation / Water balance / Simulation models / Watershed management / Water harvesting / Decision making / South East Asia ...
Sharma, Bharat R. +2 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Reflecting on twenty years of international agreements concerning water governance: insights and key learning. [PDF]
Int Environ Agreem, 2022 Mirumachi N, Hurlbert M.
europepmc +1 more source
Hydro-political assessment of water governance from the top-down and review of literature on local level institutions and practices in the Volta Basin [PDF]
Water resource management / Governance / River basin development / Water law / Colonialism / Institutions / Social participation / Women / Water ...
Ampomah B. Y. +3 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
LandThis research aims to understand the complexities of energy deployment requiring nexus governance solutions. Nexus governance involves coordinating decision-making across policy areas and sectors, seeking compromise among stakeholders with varying ...
Nadejda Komendantova +4 more
doaj +1 more source
Evolving together: transboundary water governance in the Colorado River Basin. [PDF]
Int Environ Agreem, 2021 Rivera-Torres M, Gerlak AK.
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Introducing a flat ontology into landscape research: a case study of water governance experiments in South Africa. [PDF]
Landsc Ecol, 2021 Raffn J +4 more
europepmc +1 more source
Scarperation : an empirical inquiry into the role of scarcity in fostering cooperation between international river riparians [PDF]
The environment and security literature has argued that freshwater scarcity often leads to inter-state conflict, and possibly acute violence. The contention, however, ignores the long history of hydro-political cooperation exemplified by hundreds of ...
Dinar, Ariel +2 more
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