Results 51 to 60 of about 549,261 (292)

A precipitation recycling network to assess freshwater vulnerability : challenging the watershed convention [PDF]

, 2019
Water resources and water scarcity are usually regarded as local aspects for which a watershed-based management appears adequate. However, precipitation, as a main source of freshwater, may depend on moisture supplied through land evaporation from ...
Keune, Jessica, Miralles, Diego
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Estimating and forecasting daily reference crop evapotranspiration in China with temperature-driven deep learning modelsMendeley Data

Agricultural Water Management
Accurately estimating and forecasting short-term daily reference crop evapotranspiration (ETo) is crucial for real-time irrigation decision-making and regional agricultural water management.
Jia Zhang, Yimin Ding, Lei Zhu, Yukuai Wan, Mingtang Chai, Pengpeng Ding   +5 more
doaj   +1 more source

Improving New Zealand water governance: challenges and recommendations [PDF]

, 2014
The overwhelming majority of New Zealand’s exports – not least agricultural and horticultural – require water, and in large quantities. Indeed, in many respects water is New Zealand’s largest export.
Elizabeth Eppel
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A probabilistic deep learning approach to enhance the prediction of wastewater treatment plant effluent quality under shocking load events

Water Research X
Sudden shocking load events featuring significant increases in inflow quantities or concentrations of wastewater treatment plants (WWTPs), are a major threat to the attainment of treated effluents to discharge quality standards.
Hailong Yin, Yongqi Chen, Jingshu Zhou, Yifan Xie, Qing Wei, Zuxin Xu   +5 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Supporting Water Governance and Climate Change Adaptation Through Systemic Praxis [PDF]

, 2013
Understanding and working with multiple perspectives on issues of change is an essential part of managing “common pool” water resources. In uncertain and complex situations arising from changes in human settlements and climate, both lives and livelihoods
Blackmore, Chris, Collins, Kevin, Ison, Ray   +2 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Performance comparison of a solar parabolic trough concentrator using different shapes of linear cavity receiver

Case Studies in Thermal Engineering
This study presents a numerical investigation of a solar Parabolic Trough Concentrator (PTC) with various Linear Cavity Receivers (LCRs). A linear trapezoidal cavity receiver was simulated and analyzed optically and thermally in the PTC system.
Reyhaneh Loni, Mahdi Sharifzadeh
doaj   +1 more source