Results 61 to 70 of about 5,361,862 (301)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Investigating the Effects of Land Cover Changes on Water Erosion Intensity Using the RUSLE Model in the Sahlabad Watershed [PDF]

Water Harvesting Research
Water erosion, especially in dry and semi-arid regions, is one of the most significant environmental challenges, playing a crucial role in the degradation of natural resources.
Fatemeh Jafarpour, Elham Yousefi, Mohammad Sayadi   +2 more
doaj   +1 more source

Evaluation and Simulation of Groundwater Flow in Aquifers Enclosed With Desert Saline Areas (Case Study: Isfahan Province-Ardestan Aquifer) [PDF]

Water Harvesting Research, 2018
Quantitative changes in groundwater and crises resulting from uncontrolled water extraction have turned water resources management into one of the supply-demand dilemmas in arid regions.
Saman Javadi, Hamid Kardan Moghaddam, Aminreza Neshat   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Integrated Drought Risk Assessment Using an Entropy-Weighted Fuzzy Index and Copula Functions: A Case Study of Sarbaz River Basin, Iran [PDF]

Water Harvesting Research
Drought risk assessment based on a reliable, integrated index that encompasses meteorological, hydrological, and agricultural dimensions is critical for understanding future drought trends and for implementing effective prevention and mitigation ...
Sahar Maldar, Hamid Nazaripour, Mohsen Hamidianpour   +2 more
doaj   +1 more source

Investigation on Climate Change in Meteorological Stations of Guilan Province and its Impacts on Water Balance [PDF]

Water Harvesting Research, 2018
Climate has always been changing during the lifetime of the earth, and has appeared in the form of the ice age, hurricanes, severe and sudden temperature changes, precipitation and other climatic elements, and has dramatically influenced the environment,
jalal Behzadi
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Investigating the Impacts of Climate and Land Use Change on the Hydrologic Characteristics in the Sub-Basins of the Dez River, Middle East [PDF]

Water Harvesting Research
Human activities and the climate change affects the river flow therefore monitoring flow rate of river for an extended period can reveal the detail of involved mechanisms in these changes.
Zohreh Khorsandi Kouhanestani
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Determination of Flow Parameters in Layered Rockfill Media Using Tracer Technique [PDF]

Water Harvesting Research
The present paper aims to develop improved models for predicting flow behavior, accounting for factors such as layer properties, grain size distributions, and transition zones between layers. Mathematical equations, including the Forchheimer equation and
Jafar Chabokpour
doaj   +1 more source