Results 91 to 100 of about 1,037,697 (313)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Evaluation of water stress index and water poverty in rice production based on the water footprint concept in Iran [PDF]
Introduction The increase in water demand, especially in the production of agricultural products, has led to increased competition for fresh water. Therefore, improving agricultural water productivity and reducing water stress caused by agricultural ...
Dehghanpir, Shahla +4 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Development and evaluation of a regional water poverty index for Benin: [PDF]
"The paper discusses the application of the Water Poverty Index (WPI) as a monitoring tool for Benin's water sector. Benin is currently in a process of political decentralization shifting responsibility for and administration of rural water supplies from
Heidecke, Claudia
core
Przegląd Naukowy Inżynieria i Kształtowanie Środowiska, 2020 Rivers are considered the most important sources of surface water on Earth. They are play a significant role in all human activities and the quality of river water is needed.
Sarah M. Ahmed +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Ground water pollution potential of Champaign County, Ohio
, 1995 "April, 1995."; Includes bibliographical references (pages 26-31)A ground water pollution potential map of Champaign County has been prepared using the DRASTIC mapping process.
Jones, A. Wayne
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An Effective Water Body Extraction Method with New Water Index for Sentinel-2 Imagery
, 2021 Surface water bodies, such as rivers, lakes, and reservoirs, play an irreplaceable role in global ecosystems and climate systems. Sentinel-2 imagery provides new high-resolution satellite remote sensing data.
Hongrun Ju +9 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source