Results 101 to 110 of about 902,226 (264)
Frontiers in Ecology and EvolutionSeasonal water-level fluctuations associated with hydroelectric reservoir management can generate littoral disturbances, with consequences for the sustainability of Lake Trout (Salvelinus namaycush) populations across North America.
Marie-Joëlle Lauzier +9 more
doaj +1 more source
سلامت و محیط, 2022 Background and Objective: Increasing the productivity of surface water, the unsustainable development of agriculture in the boundaries of rivers, and human sewage have reduced the quality of these water resources.
Houshang Ghamarnia +2 more
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
WATER QUALITY INDEX – AN INSTRUMENT FOR WATER RESOURCES MANAGEMENT [PDF]
Aerul şi Apa: Componente ale Mediului, 2014 Water quality status assessment can be defined as the evaluation of physical, chemical, biological state of the water in relation with the natural state, anthropogenic effects and future uses.
PAIU MĂDĂLINA +1 more
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
WATER QUALITY INDEX IN AN URBAN WATERSHED [PDF]
International Journal of Sustainable Development and Planning, 2016 Raissa C. Gomes +5 more
openaire +1 more source
WATER QUALITY INDEX PREDICTION
international journal of engineering technology and management sciencesWater is perhaps the most precious natural resource after air. Though the surface of the earth mostly consists of water, only a small part of it is usable, which makes this resource limited. This Precious and limited resource, therefore, must be used with care.
null S V HEMANTH +2 more
openaire +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source