Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Effects of changes in veno-venous extracorporeal membrane oxygenation blood flow on the measurement of intrathoracic blood volume and extravascular lung water index: a prospective interventional study. [PDF]
J Clin Monit Comput, 2023 Conrad AM +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Development and evaluation of a regional water poverty index for Benin: [PDF]
"The paper discusses the application of the Water Poverty Index (WPI) as a monitoring tool for Benin's water sector. Benin is currently in a process of political decentralization shifting responsibility for and administration of rural water supplies from
Heidecke, Claudia
core
Extravascular lung water index, pulmonary vascular permeability index, and global end-diastolic volume index in mechanically ventilated COVID-19 patients requiring prone position ventilation: a preliminary retrospective study. [PDF]
Acute Crit Care, 2022 De Rosa RC +5 more
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Water Marketing-Surplus Water Reports, 2018
, 2017 application/pdf; Report covers Calendar Year 2018; "December 2017.""Surplus water is defined as waters within the conservation water supply capacity committed to the State, but not required to meet contractual requirements.
Kansas Water Office.
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Research on Wetland Vegetation Classification of Chongming Eastern Tidal Flat Based on TM Image
Shuitu baochi yanjiu, 2013 Remote sensing classification of wetland vegetation is of great importance to wetland ecosystem conservation and management.The classification of wetland vegetation are difficult because of the intricate environment and the similar vegetation spectrum ...
YANG Li-jun1 +2 more
doaj
Increased extravascular lung water index (EVLWI) reflects rapid non-cardiogenic oedema and mortality in COVID-19 associated ARDS. [PDF]
Sci Rep, 2021 Rasch S +12 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source