Results 131 to 140 of about 1,037,697 (313)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Evaluation on water quality index for river water quality management
, 2014 碩士河川污染指標(River pollution index, RPI)與水質指標(Water quality index, WQI)可表達河川水體水質良窳，環保署應用RPI於河川水質管理，RPI水質參數包含SS、BOD、DO與NH3-N。本研究目的:(1)檢討RPI與水質項目之相關性、(2)檢討RPI與WQI之相關性、及(3)評估WQI取代RPI於河川水質管理。水質資料以環保署2007-2011年全國流域水質監測資料為統計對象。研究結果顯示RPI無法表示水質濃度差異，RPI值隨BOD、NH3 ...
張祚楨; Chang, Tso-Chen
core
WATER QUALITY INDEX IN AN URBAN WATERSHED [PDF]
International Journal of Sustainable Development and Planning, 2016 Raissa C. Gomes +5 more
openaire +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Burning-induced electrical signals influence broadband reflectance indices and water index in pea leaves. [PDF]
Plant Signal Behav, 2020 Sukhova E +5 more
europepmc +1 more source
WATER QUALITY INDEX PREDICTION
international journal of engineering technology and management sciencesWater is perhaps the most precious natural resource after air. Though the surface of the earth mostly consists of water, only a small part of it is usable, which makes this resource limited. This Precious and limited resource, therefore, must be used with care.
null S V HEMANTH +2 more
openaire +1 more source