Results 161 to 170 of about 2,609,914 (372)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Analisis Indeks Kualitas Air Lingkungan Pertambangan Batubara PT Kpc Subdas Sangatta Kalimantan Timur [PDF]

open access: yes, 2011
Water quality index (IKA) is one tool to quickly predict the environmental quality status of an ecosystem or region to obtaining an alternative of the future management.
Komarawidjaja, W. (Wage)
core  

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Water Quality in the Dam Site of the Koto Panjang Dam Based on Chemical Index [PDF]

open access: yes, 2015
In floating cage fish culture activities, fish feed remains and feces are freed to surrounding water. Degradation of these materials decreases the water quality in general.
Adriman, A. (Adriman)   +2 more
core  

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

Studies of Relation Between Turbidity and Refractive Indeks of Bottled Water in the Area of Banda Aceh by Using Interferometer Murty Method [PDF]

open access: yes, 2012
Bottled water is clean water ready to drink quickly without cooking however, it is not all of the bottled water have a good quality. The quality of water can be observed from the optical properties of water, such as clarity and refractive index.
Idris, N. (Nasrullah)   +2 more
core  

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

open access: yesMolecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef   +10 more
wiley   +1 more source

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