Results 51 to 60 of about 12,262,922 (372)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Predicting salinity levels in the Mekong delta (Viet Nam): analysis of machine learning and deep learning models

Discover Artificial Intelligence
Salinity intrusion stands out as a severe yet escalating challenge facing the water resource management and agricultural production of the Mekong Delta in Vietnam as a result of climate change and upstream hydrological changes.
Phong Nguyen Duc, Thang Tang Duc, Giap Pham Van, Hoat Nguyen Van, Tuan Tran Minh   +4 more
doaj   +1 more source

Increasing dependence of lowland populations on mountain water resources

Nature Sustainability, 2020
Mountain areas provide disproportionally high runoff in many parts of the world, but their importance for water resources and food production has not been clarified from the viewpoint of the lowland areas downstream.
D. Viviroli, M. Kummu, M. Meybeck, M. Kallio, Y. Wada   +4 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Irrigation water pricing based on the ELES-WPTI model in the Yinda-Jihuang project of China

Water Policy, 2023
Water pricing is the key to maximizing the economic and social benefits of the water transfer project. In this study, we propose the extended linear expenditure system-water price tolerance index (ELES-WPTI) model that combines the ELES model and the ...
He Chen, Ting Wang, Guohua Fang, Huaxiang He, Xinmin Xie, Mingwan Yin, Ping Xiao   +6 more
doaj   +1 more source

Climate change vulnerability, water resources and social implications in North Africa

Regional Environmental Change, 2020
North Africa is considered a climate change hot spot. Existing studies either focus on the physical aspects of climate change or discuss the social ones.
J. Schilling, E. Hertig, Y. Tramblay, J. Scheffran   +3 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A deep learning runoff prediction model based on wavelet decomposition and dynamic feature fusion

Scientific Reports
To address the stochasticity, time-varying characteristics, and nonlinear dynamics of runoff series, this research proposes a novel deep learning architecture, BWDformer, based on wavelet decomposition and dynamic feature fusion, to enhance the precision
Dong-mei Xu, Qi-qi Zeng, Wen-chuan Wang, Xu-tong Zhang, Yi-yang Wang, Hong-fei Zang   +5 more
doaj   +1 more source

Potential health risk and levels of heavy metals in water resources of lead–zinc mining communities of Abakaliki, southeast Nigeria

Applied Water Science, 2020
Heavy metals are potential health risk, especially in mining sites where they deteriorate from sulfide-rich ore bodies. Lead, cadmium, arsenic and mercury are very carcinogenic, while others are toxic.
P. Obasi, B. Akudinobi
semanticscholar   +1 more source

Water saving through international trade of agricultural products [PDF]

, 2005
Many nations save domestic water resources by importing water-intensive products and exporting commodities that are less water intensive. National water saving through the import of a product can imply saving water at a global level if the flow is from ...
Chapagain, A.K., Hoekstra, A.Y., Savenije, H.H.G.   +2 more
core   +5 more sources