Results 91 to 100 of about 8,365,932 (359)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Optimizing water and nitrogen management to reduce basal nitrogen inputs, improve nitrogen uptake and utilization efficiencies, and achieve high yields and low soil nitrate residue in wheat production

Crop and Environment
Excessive basal nitrogen (N) inputs and improper water management limit both wheat yields and N use efficiency. Thus, a field experiment was conducted for two years to evaluate whether optimizing water and N management could reduce basal N inputs ...
Wen Li, Yuyan Fan, Qiu Yang, Wen Lin, Jianfu Xue, Yuechao Wang, Zhiqiang Gao   +6 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Drone-Based Hyperspectral and Thermal Imagery for Quantifying Upland Rice Growth and Water Use Efficiency After Biochar Application

, 2021
Hongxiao Jin, Christian Josef Köppl, Benjamin Fischer, Johanna Rojas Conejo, Mark S. Johnson, Laura Morillas, Steve W. Lyon, Ana María Durán‐Quesada, Andrea Suárez Serrano, Stefano Manzoni, Mónica García   +10 more
openalex   +2 more sources

Assessment of Water Quality in Tigris River of AL-Kut City, Iraq by Using GIS [PDF]

, 2021
Hussein J. Khadim, Hasanain Owaid Oleiwi
openalex   +1 more source

Water saving through international trade of agricultural products [PDF]

, 2005
Many nations save domestic water resources by importing water-intensive products and exporting commodities that are less water intensive. National water saving through the import of a product can imply saving water at a global level if the flow is from ...
Chapagain, A.K., Hoekstra, A.Y., Savenije, H.H.G.   +2 more
core   +5 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Almond yield prediction at orchard scale using satellite-derived biophysical traits and crop evapotranspiration combined with machine learning

Frontiers in Agronomy
Accurate almond yield prediction is essential for supporting decision-making across multiple scales, from individual growers to international markets.
Manuel Quintanilla-Albornoz, Manuel Quintanilla-Albornoz, Xavier Miarnau, Magi Pamies-Sans, Joaquim Bellvert   +4 more
doaj   +1 more source

Strategic Actions for Increasing the Submission of Digital Cadastral Data by the Surveying Industry Based on Lessons Learned from Victoria, Australia

ISPRS International Journal of Geo-Information, 2018
ePlan, as a digital cadastral data initiative, is a collaborative program between the land authorities and the surveying industry which aims to replace paper and PDF cadastral plans and surveys with digital data.
Hamed Olfat, Davood Shojaei, Mark Briffa, Susannah Maley, Abbas Rajabifard   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source